Severe topiramate-associated hyperthermia resulting in persistent neurological dysfunction

Sharon C. Galicia, Steven L. Lewis*, Leo Verhagen Metman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Topiramate has recently been reported to cause hyperthermia as a result of oligohydrosis, primarily in pediatric patients. All cases reported to date were clinically mild, without permanent systemic or neurologic dysfunction. We report a case of severe hyperthermia and subsequent ataxia and tremor in an adult treated with topiramate. To our knowledge, this is the first case of topiramate-associated hyperthermia to result in residual cerebellar and cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)94-95
Number of pages2
JournalClinical neuropharmacology
Volume28
Issue number2
DOIs
StatePublished - Mar 2005

Keywords

  • Cerebellar dysfunction
  • Hyperthermia
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology

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