Abstract
It is an unmet need to estimate survival duration for patients with progressive supranuclear palsy (PSP). The objective of this study was to identify factors associated with the survival duration in patients with PSP. We followed up 23 patients with probable PSP-RS (Richardson syndrome) or PSP-P (parkinsonism) in our PSP center until death from 2011 to 2019. We prospectively and quantitatively rated their downgaze palsy whenever first noticed in our clinic. This was utilized along with the disease duration, motor function, medication use for parkinsonism, sex, age at onset of PSP, comorbid pulmonary and cardiovascular diseases, and the total survival duration from the onset of PSP to death for prediction analysis. A well-fitted linear regression model and a multivariant Cox model were applied to identify predicting factors for total survival duration. All patients had the specific hummingbird sign on brain MRI for PSP when downgaze palsy was documented. We found that the severity of downgaze palsy and the disease duration at the assessment were consistently correlated with the total survival duration in both models. The total survival duration could be further estimated by a formed regression equation. We conclude that severity and time to develop downgaze palsy could help to estimate the total survival duration in patients with probable PSP-RS and PSP-P, the major forms of PSP, which has significant clinical applications in clinical counseling and trial enrollment.
Original language | English (US) |
---|---|
Article number | 736784 |
Journal | Frontiers in Neurology |
Volume | 12 |
DOIs | |
State | Published - Sep 28 2021 |
Funding
22. Picillo M, Abate F, Pontivorvo S, Tepedino MF, Erro R, Frosini D, et al. Association of MRI measures with disease severity and progression in progressive supranuclear palsy. Front Neurol. (2020) 11:603161. doi: 10.3389/fneur.2020.603161 Conflict of Interest: TX has been supported in research by the Michael J Fox Foundation for Parkinson’s Research and Parkinson’s Foundation, and received honoraria from CVS Caremark for consultation and from Parkinson’s Foundation for study sessions.
Keywords
- PSP
- disease duration
- downgaze palsy
- factors
- severity
- survival duration
ASJC Scopus subject areas
- Neurology
- Clinical Neurology