Sex Differences in Heart Failure

ANURADHA Lala*, UPASANA TAYAL, CARINE E. HAMO, QUENTIN YOUMANS, SANA M. AL-KHATIB, BIYKEM BOZKURT, MELINDA B. DAVIS, JAMES JANUZZI, ROBERT MENTZ, ANDREW SAUER, MARY NORINE WALSH, CLYDE YANCY, MARTHA GULATI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Heart failure (HF) continues to be a major contributor of morbidity and mortality for men and women alike, yet how the predisposition for, course and management of HF differ between men and women remains underexplored. Sex differences in traditional risk factors as well as sex-specific risk factors influence the prevalence and manifestation of HF in unique ways. The pathophysiology of HF differs between men and women and may explain sex-specific differences in clinical presentation and diagnosis. This in turn, contributes to variation in response to both pharmacologic and device/surgical therapy. This review examines sex-specific differences in HF spanning prevalence, risk factors, pathophysiology, presentation, and therapies with a specific focus on highlighting gaps in knowledge with calls to action for future research efforts.

Original languageEnglish (US)
Pages (from-to)477-498
Number of pages22
JournalJournal of Cardiac Failure
Volume28
Issue number3
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • Heart failure
  • cardiovascular disease
  • sex differences
  • women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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