@article{b242b891536c46398845681ec0d45287,
title = "Sex-specific impact of asthma during pregnancy on infant gut microbiota",
abstract = "Asthma during pregnancy is associated with retardation of fetal growth in a sex-specific manner. Lactobacilli microbes influence infant growth. This study aimed to determine whether lactobacilli and other microbes are reduced in the gut of infants born to an asthmatic mother, and whether this differs by the sex of the infant. Mother-infant pairs (N=1021) from the Canadian Healthy Infant Longitudinal Development full-term cohort were studied. The abundance of infant faecal microbiota at 3-4 months, profiled by gene sequencing, was compared between both women with and without asthma treatment during pregnancy. Infant sex, maternal ethnicity, pre-pregnancy overweight and atopy status, birth mode, breastfeeding status and intrapartum antibiotic treatment were tested as covariates. Independent of birth mode and other covariates, male, Caucasian infants born to women with prenatal asthma harboured fewer lactobacilli in the gut at 3-4 months of age. If asthmatic mothers had pre-pregnancy overweight, the abundance of Lactobacillus in males was further reduced in the infant gut, whereas the microbiota of female infants was enriched with Bacteroidaceae. Similar differences in infant gut microbial composition according to maternal prenatal asthma status were also more evident among women with food or environmental allergies. Gut lactobacilli were less abundant in male infants, but Bacteroidaceae were more abundant in female infants at 3-4 months of age, following maternal asthma during pregnancy.",
author = "{the CHILD Study Investigators} and Koleva, {Petya T.} and Tun, {Hein M.} and Theodore Konya and Guttman, {David S.} and Becker, {Allan B.} and Mandhane, {Piush J.} and Turvey, {Stuart E.} and Padmaja Subbarao and Sears, {Malcolm R.} and Scott, {James A.} and Kozyrskyj, {Anita L.} and Anand, {S. S.} and Azad, {M. B.} and Becker, {A. B.} and Befus, {A. D.} and M. Brauer and Brook, {J. R.} and E. Chen and Cyr, {M. M.} and D. Daley and Dell, {S. D.} and Denburg, {J. A.} and Duan, {Q. L.} and T. Eiwegger and H. Grasemann and K. HayGlass and Hegele, {R. G.} and Holness, {D. L.} and P. Hystad and M. Kobor and Kollmann, {T. R.} and C. Laprise and Lou, {W. Y.W.} and J. Macri and Mandhane, {P. J.} and G. Miller and Moraes, {T. J.} and P. Par{\'e} and C. Ramsey and F. Ratjen and A. Sandford and J. Scott and Scott, {J. A.} and Sears, {M. R.} and F. Silverman and E. Simons and P. Subbarao and T. Takaro and Tebbutt, {S. J.} and T. To",
note = "Funding Information: The Canadian Institutes of Health Research (CIHR) and the Allergy, Genes and Environment (AllerGen) Network of Centres of Excellence provided core support for the CHILD study. The study was specifically funded by the CIHR Microbiome Initiative team grant, #227312. Funding information for this article has been deposited with the Crossref Funder Registry We are grateful to all the families who took part in this study, and the whole CHILD team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. We thank Sarah Bridgman for her assistance in formatting the final version of the manuscript and Konstantin Shestopaloff for completing the ART tests. Anita Kozyrskyj will serve as the guarantor for the contents of this paper. Funding Information: Support statement: The Canadian Institutes of Health Research (CIHR) and the Allergy, Genes and Environment (AllerGen) Network of Centres of Excellence provided core support for the CHILD study. The study was specifically funded by the CIHR Microbiome Initiative team grant, #227312. Funding information for this article has been deposited with the Crossref Funder Registry Publisher Copyright: Copyright {\textcopyright} ERS 2017. This ERJ Open article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.",
year = "2017",
month = nov,
day = "1",
doi = "10.1183/13993003.00280-2017",
language = "English (US)",
volume = "50",
journal = "Scandinavian Journal of Respiratory Diseases",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",
}