Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). Conclusion: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
- Biomathematical models
- Sex differences
ASJC Scopus subject areas
- Cancer Research
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Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Whitmire, P. (Creator), Rickertsen, C. R. (Creator), Hawkins-Daarud, A. (Creator), Carrasco, E. (Creator), Lorence, J. (Creator), De Leon, G. (Contributor), Curtin, L. (Creator), Bayless, S. (Creator), Clark-Swanson, K. (Creator), Peeri, N. C. (Creator), Corpuz, C. (Creator), Lewis-De Los Angeles, C. P. (Contributor), Bendok, B. R. (Creator), Gonzalez-Cuyar, L. (Creator), Vora, S. (Contributor), Mrugala, M. M. (Creator), Hu, L. S. (Creator), Wang, L. (Creator), Porter, A. (Contributor), Kumthekar, P. U. (Creator), Johnston, S. K. (Creator), Egan, K. M. (Creator), Gatenby, R. (Creator), Canoll, P. (Creator), Rubin, J. B. (Creator), Swanson, K. R. (Creator), Leon, G. D. (Creator), Mrugala, M. M. (Creator) & Gatenby, R. (Creator), figshare, 2020