Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

Paula Whitmire*, Cassandra R. Rickertsen, Andrea Hawkins-Daarud, Eduardo Carrasco, Julia Lorence, Gustavo De Leon, Lee Curtin, Spencer Bayless, Kamala Clark-Swanson, Noah C. Peeri, Christina Corpuz, Christine Paula Lewis-De Los Angeles, Bernard R. Bendok, Luis Gonzalez-Cuyar, Sujay Vora, Maciej M. Mrugala, Leland S. Hu, Lei Wang, Alyx Porter, Priya KumthekarSandra K. Johnston, Kathleen M. Egan, Robert Gatenby, Peter Canoll, Joshua B. Rubin, Kristin R. Swanson

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). Conclusion: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.

Original languageEnglish (US)
Article number447
JournalBMC cancer
Volume20
Issue number1
DOIs
StatePublished - May 19 2020

Keywords

  • Biomathematical models
  • Glioblastoma
  • Neuroimaging
  • Sex differences

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

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    Whitmire, P., Rickertsen, C. R., Hawkins-Daarud, A., Carrasco, E., Lorence, J., De Leon, G., Curtin, L., Bayless, S., Clark-Swanson, K., Peeri, N. C., Corpuz, C., Lewis-De Los Angeles, C. P., Bendok, B. R., Gonzalez-Cuyar, L., Vora, S., Mrugala, M. M., Hu, L. S., Wang, L., Porter, A., ... Swanson, K. R. (2020). Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients. BMC cancer, 20(1), [447]. https://doi.org/10.1186/s12885-020-06816-2