Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018

Ethan Morgan; Elissa Meites; Lauri E. Markowitz; Casey D. Xavier Hall; Troy D. Querec; Elizabeth R. Unger; Richard A. Crosby; Michael E. Newcomb; Brian Mustanski

doi:10.1097/OLQ.0000000000001433

Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018

Ethan Morgan, Elissa Meites, Lauri E. Markowitz, Casey D. Xavier Hall, Troy D. Querec, Elizabeth R. Unger, Richard A. Crosby, Michael E. Newcomb, Brian Mustanski

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States; men who have sex with men (MSM) have higher prevalence of infection and related disease compared with other men. We assessed whether differences in HPV acquisition exist among MSM according to their sexual positioning practices, as well as self-reported receipt of HPV vaccination. Methods We enrolled young MSM and transgender women aged 18 to 26 years in Chicago, IL (N = 666). Participants self-reported their history of HPV vaccination and submitted self-collected anal swab specimens for type-specific HPV detection using an L1-consensus PCR assay. Multivariable logistic regression analyses were used to assess relationships between sexual positioning practices and detection of any HPV or quadrivalent HPV vaccine (4vHPV) types by vaccination status, defined as self-reported receipt of ≥1 HPV vaccine dose versus none. Results Among 666 participants, 400 (60.1%) had any anal HPV, and 146 (21.9%) had a 4vHPV type. Among vaccinated participants, 18, 36, and 177 reported exclusively insertive, exclusively receptive, or both sexual positioning practices, respectively. Compared with participants reporting exclusively insertive anal sex, odds of any HPV were significantly higher among participants engaging exclusively in receptive anal sex (adjusted odds ratio [aOR], 5.90; 95% confidence interval [CI], 2.52-13.78), as well as those engaging in both (aOR, 3.32; 95% CI, 1.71-6.44). Vaccinated participants, compared with unvaccinated participants, had lower odds of 4vHPV-type HPV regardless of sexual positioning practices (aOR, 0.56; 95% CI, 0.34-0.92). Conclusions Adult men and transgender women who practice anal receptive sex have high prevalence of infection with any HPV. Routine vaccination of all adolescents is expected to reduce HPV-related disease incidence among adult MSM and transgender women as vaccinated cohorts age.

Original language	English (US)
Pages (from-to)	709-713
Number of pages	5
Journal	Sexually Transmitted Diseases
Volume	48
Issue number	10
DOIs	https://doi.org/10.1097/OLQ.0000000000001433
State	Published - Oct 1 2021

Funding

Sources of Funding: The VIM study was funded by the Centers for Disease Control and Prevention (U48DP005014). The RADAR study was supported by a grant from the National Institute on Drug Abuse at the National Institutes of Health (F32DA046313, PI: Morgan; U01DA036939, PI: Mustanski).

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Microbiology (medical)
Infectious Diseases
Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/OLQ.0000000000001433

Cite this

Morgan, E., Meites, E., Markowitz, L. E., Xavier Hall, C. D., Querec, T. D., Unger, E. R., Crosby, R. A., Newcomb, M. E., & Mustanski, B. (2021). Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018. Sexually Transmitted Diseases, 48(10), 709-713. https://doi.org/10.1097/OLQ.0000000000001433

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title = "Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018",

abstract = "Background Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States; men who have sex with men (MSM) have higher prevalence of infection and related disease compared with other men. We assessed whether differences in HPV acquisition exist among MSM according to their sexual positioning practices, as well as self-reported receipt of HPV vaccination. Methods We enrolled young MSM and transgender women aged 18 to 26 years in Chicago, IL (N = 666). Participants self-reported their history of HPV vaccination and submitted self-collected anal swab specimens for type-specific HPV detection using an L1-consensus PCR assay. Multivariable logistic regression analyses were used to assess relationships between sexual positioning practices and detection of any HPV or quadrivalent HPV vaccine (4vHPV) types by vaccination status, defined as self-reported receipt of ≥1 HPV vaccine dose versus none. Results Among 666 participants, 400 (60.1%) had any anal HPV, and 146 (21.9%) had a 4vHPV type. Among vaccinated participants, 18, 36, and 177 reported exclusively insertive, exclusively receptive, or both sexual positioning practices, respectively. Compared with participants reporting exclusively insertive anal sex, odds of any HPV were significantly higher among participants engaging exclusively in receptive anal sex (adjusted odds ratio [aOR], 5.90; 95% confidence interval [CI], 2.52-13.78), as well as those engaging in both (aOR, 3.32; 95% CI, 1.71-6.44). Vaccinated participants, compared with unvaccinated participants, had lower odds of 4vHPV-type HPV regardless of sexual positioning practices (aOR, 0.56; 95% CI, 0.34-0.92). Conclusions Adult men and transgender women who practice anal receptive sex have high prevalence of infection with any HPV. Routine vaccination of all adolescents is expected to reduce HPV-related disease incidence among adult MSM and transgender women as vaccinated cohorts age.",

author = "Ethan Morgan and Elissa Meites and Markowitz, {Lauri E.} and {Xavier Hall}, {Casey D.} and Querec, {Troy D.} and Unger, {Elizabeth R.} and Crosby, {Richard A.} and Newcomb, {Michael E.} and Brian Mustanski",

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year = "2021",

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doi = "10.1097/OLQ.0000000000001433",

language = "English (US)",

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Morgan, E, Meites, E, Markowitz, LE, Xavier Hall, CD, Querec, TD, Unger, ER, Crosby, RA, Newcomb, ME & Mustanski, B 2021, 'Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018', Sexually Transmitted Diseases, vol. 48, no. 10, pp. 709-713. https://doi.org/10.1097/OLQ.0000000000001433

TY - JOUR

T1 - Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018

AU - Morgan, Ethan

AU - Meites, Elissa

AU - Markowitz, Lauri E.

AU - Xavier Hall, Casey D.

AU - Querec, Troy D.

AU - Unger, Elizabeth R.

AU - Crosby, Richard A.

AU - Newcomb, Michael E.

AU - Mustanski, Brian

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Background Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States; men who have sex with men (MSM) have higher prevalence of infection and related disease compared with other men. We assessed whether differences in HPV acquisition exist among MSM according to their sexual positioning practices, as well as self-reported receipt of HPV vaccination. Methods We enrolled young MSM and transgender women aged 18 to 26 years in Chicago, IL (N = 666). Participants self-reported their history of HPV vaccination and submitted self-collected anal swab specimens for type-specific HPV detection using an L1-consensus PCR assay. Multivariable logistic regression analyses were used to assess relationships between sexual positioning practices and detection of any HPV or quadrivalent HPV vaccine (4vHPV) types by vaccination status, defined as self-reported receipt of ≥1 HPV vaccine dose versus none. Results Among 666 participants, 400 (60.1%) had any anal HPV, and 146 (21.9%) had a 4vHPV type. Among vaccinated participants, 18, 36, and 177 reported exclusively insertive, exclusively receptive, or both sexual positioning practices, respectively. Compared with participants reporting exclusively insertive anal sex, odds of any HPV were significantly higher among participants engaging exclusively in receptive anal sex (adjusted odds ratio [aOR], 5.90; 95% confidence interval [CI], 2.52-13.78), as well as those engaging in both (aOR, 3.32; 95% CI, 1.71-6.44). Vaccinated participants, compared with unvaccinated participants, had lower odds of 4vHPV-type HPV regardless of sexual positioning practices (aOR, 0.56; 95% CI, 0.34-0.92). Conclusions Adult men and transgender women who practice anal receptive sex have high prevalence of infection with any HPV. Routine vaccination of all adolescents is expected to reduce HPV-related disease incidence among adult MSM and transgender women as vaccinated cohorts age.

AB - Background Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States; men who have sex with men (MSM) have higher prevalence of infection and related disease compared with other men. We assessed whether differences in HPV acquisition exist among MSM according to their sexual positioning practices, as well as self-reported receipt of HPV vaccination. Methods We enrolled young MSM and transgender women aged 18 to 26 years in Chicago, IL (N = 666). Participants self-reported their history of HPV vaccination and submitted self-collected anal swab specimens for type-specific HPV detection using an L1-consensus PCR assay. Multivariable logistic regression analyses were used to assess relationships between sexual positioning practices and detection of any HPV or quadrivalent HPV vaccine (4vHPV) types by vaccination status, defined as self-reported receipt of ≥1 HPV vaccine dose versus none. Results Among 666 participants, 400 (60.1%) had any anal HPV, and 146 (21.9%) had a 4vHPV type. Among vaccinated participants, 18, 36, and 177 reported exclusively insertive, exclusively receptive, or both sexual positioning practices, respectively. Compared with participants reporting exclusively insertive anal sex, odds of any HPV were significantly higher among participants engaging exclusively in receptive anal sex (adjusted odds ratio [aOR], 5.90; 95% confidence interval [CI], 2.52-13.78), as well as those engaging in both (aOR, 3.32; 95% CI, 1.71-6.44). Vaccinated participants, compared with unvaccinated participants, had lower odds of 4vHPV-type HPV regardless of sexual positioning practices (aOR, 0.56; 95% CI, 0.34-0.92). Conclusions Adult men and transgender women who practice anal receptive sex have high prevalence of infection with any HPV. Routine vaccination of all adolescents is expected to reduce HPV-related disease incidence among adult MSM and transgender women as vaccinated cohorts age.

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Sexual Positioning Practices and Anal Human Papillomavirus Infection among Young Men Who Have Sex with Men and Transgender Women - Chicago, Illinois, 2016-2018

Abstract

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UN SDGs

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