@article{d336e91354fa471496255bf0ce649a07,
title = "SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells",
abstract = "Mason et al. report that SGK1 promotes survival of cells detached from extracellular matrix through a mechanism dependent on elevated glucose uptake and ATP generation. This increased bioenergetic capacity requires pentose phosphate pathway (PPP) flux. Defects in SGK1-mediated ATP generation can be rescued with exogenous glyceraldehyde-3-phosphate or GAPDH activation.",
keywords = "SGK1, anoikis, glucose metabolism, pentose phosphate pathway, signal transduction",
author = "Mason, {Joshua A.} and Cockfield, {Jordan A.} and Pape, {Daniel J.} and Hannah Meissner and Sokolowski, {Michael T.} and White, {Taylor C.} and {Valent{\'i}n L{\'o}pez}, {Jos{\'e} C.} and Juan Liu and Xiaojing Liu and Inmaculada Mart{\'i}nez-Reyes and Chandel, {Navdeep S.} and Locasale, {Jason W.} and Schafer, {Zachary T.}",
note = "Funding Information: We thank Veronica Schafer and all current and past Schafer laboratory members for helpful comments, experimental assistance, and/or valuable discussion. We also thank Mary Ann McDowell (Notre Dame) for assistance with immunofluorescence and Kevin T. Vaughan (Notre Dame) for help with soft agar. We thank Dr. Junichi Kurebayashi (Kawasaki Medical School) for the KPL-4 cell line, Dr. Jing Yang (UCSD) for the 4T07 cells line, and Dr. Suzanne Conzen (UT Southwestern) for the SGK1 constructs. The graphical abstract and model in Figure 7 K were created with BioRender.com . This work was supported by a Lee National Denim Day Research Scholar Grant (RSG-14-145-01) from the American Cancer Society (to Z.T.S.), a research grant from the Phi Beta Psi National Project (to Z.T.S.), the Coleman Foundation , the College of Science at the University of Notre Dame , and a Research Experience for Undergraduates grant from the National Science Foundation . We are also grateful for support from the Malanga Family Excellence Fund for Cancer Research , whose benefactors, Ron and Rosemarie Malanga, have enabled successful completion of this project. Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = mar,
day = "16",
doi = "10.1016/j.celrep.2021.108821",
language = "English (US)",
volume = "34",
journal = "Cell reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}