SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

Joshua A. Mason, Jordan A. Cockfield, Daniel J. Pape, Hannah Meissner, Michael T. Sokolowski, Taylor C. White, José C. Valentín López, Juan Liu, Xiaojing Liu, Inmaculada Martínez-Reyes, Navdeep S. Chandel, Jason W. Locasale, Zachary T. Schafer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Mason et al. report that SGK1 promotes survival of cells detached from extracellular matrix through a mechanism dependent on elevated glucose uptake and ATP generation. This increased bioenergetic capacity requires pentose phosphate pathway (PPP) flux. Defects in SGK1-mediated ATP generation can be rescued with exogenous glyceraldehyde-3-phosphate or GAPDH activation.

Original languageEnglish (US)
Article number108821
JournalCell reports
Volume34
Issue number11
DOIs
StatePublished - Mar 16 2021

Keywords

  • SGK1
  • anoikis
  • glucose metabolism
  • pentose phosphate pathway
  • signal transduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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