Shape-control of protein crystals in patterned microwells

Liying Wang, Hyung Lee Min, Jeremy Barton, Laura Hughes, Teri W. Odom*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


This Communication demonstrates how selectively functionalized, patterned microscale wells can be used as small-volume (fL) crystallization vessels to grow protein crystals. This surface-patterned approach enables proteins to be crystallized with well-controlled shapes and uniform sizes from 3 μm down to 600 nm. Three different proteins - lysozyme, thaumatin, and glucose isomerase - were crystallized as model systems to demonstrate the generality of this technique. Different polymorphs were formed simply by controlling the evaporation conditions.

Original languageEnglish (US)
Pages (from-to)2142-2143
Number of pages2
JournalJournal of the American Chemical Society
Issue number7
StatePublished - Feb 20 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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