Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Hiam Abdala-Valencia, Mackenzie E. Coden, Sergio E. Chiarella, Elizabeth A. Jacobsen, Bruce Scott Bochner, James J. Lee, Sergejs Berdnikovs

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Eosinophils play homeostatic roles in different tissues and are found in several organs at a homeostatic baseline, though their tissue numbers increase significantly in development and disease. The morphological, phenotypical, and functional plasticity of recruited eosinophils are influenced by the dynamic tissue microenvironment changes between homeostatic, morphogenetic, and disease states. Activity of the epithelial-mesenchymal interface, extracellular matrix, hormonal inputs, metabolic state of the environment, as well as epithelial and mesenchymal-derived innate cytokines and growth factors all have the potential to regulate the attraction, retention, in situ hematopoiesis, phenotype, and function of eosinophils. This review examines the reciprocal relationship between eosinophils and such tissue factors, specifically addressing: (1) tissue microenvironments associated with the presence and activity of eosinophils; (2) non-immune tissue ligands regulatory for eosinophil accumulation, hematopoiesis, phenotype, and function (with an emphasis on the extracellular matrix and epithelial–mesenchymal interface); (3) the contribution of eosinophils to regulating tissue biology; (4) eosinophil phenotypic heterogeneity in different tissue microenvironments, classifying eosinophils as progenitors, steady state eosinophils, and Type 1 and 2 activated phenotypes. An appreciation of eosinophil regulation by non-immune tissue factors is necessary for completing the picture of eosinophil immune activation and understanding the functional contribution of these cells to development, homeostasis, and disease.

Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalJournal of Leukocyte Biology
Volume104
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Eosinophils
Homeostasis
Hematopoiesis
Thromboplastin
Phenotype
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Cytokines
Ligands

Keywords

  • asthma
  • development
  • eosinophils
  • epithelium
  • extracellular matrix
  • homeostasis
  • in situ hematopoiesis
  • mesenchyme
  • metabolism
  • phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Abdala-Valencia, Hiam ; Coden, Mackenzie E. ; Chiarella, Sergio E. ; Jacobsen, Elizabeth A. ; Bochner, Bruce Scott ; Lee, James J. ; Berdnikovs, Sergejs. / Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease. In: Journal of Leukocyte Biology. 2018 ; Vol. 104, No. 1. pp. 95-108.
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Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease. / Abdala-Valencia, Hiam; Coden, Mackenzie E.; Chiarella, Sergio E.; Jacobsen, Elizabeth A.; Bochner, Bruce Scott; Lee, James J.; Berdnikovs, Sergejs.

In: Journal of Leukocyte Biology, Vol. 104, No. 1, 01.07.2018, p. 95-108.

Research output: Contribution to journalReview article

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AU - Abdala-Valencia, Hiam

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