Shaping proteostasis at the cellular, tissue, and organismal level

Ambre J. Sala, Laura C. Bott, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases. In multicellular organisms, the PN is regulated at the cellular, tissue, and systemic level to ensure organismal health and longevity. Here we review these three layers of PN regulation and examine how they collectively maintain cellular homeostasis, achieve cell type-specific proteomes, and coordinate proteostasis across tissues. A precise understanding of these layers of control has important implications for organismal health and could offer new therapeutic approaches for neurodegenerative diseases and other chronic disorders related to PN dysfunction.

Original languageEnglish (US)
Pages (from-to)1231-1241
Number of pages11
JournalJournal of Cell Biology
Volume216
Issue number5
DOIs
StatePublished - May 1 2017

ASJC Scopus subject areas

  • Cell Biology

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