Shared parameter models for the joint analysis of longitudinal data and event times

Edward F. Vonesh*, Tom Greene, Mark D. Schluchter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Longitudinal studies often gather joint information on time to some event (survival analysis, time to dropout) and serial outcome measures (repeated measures, growth curves). Depending on the purpose of the study, one may wish to estimate and compare serial trends over time while accounting for possibly non-ignorable dropout or one may wish to investigate any associations that may exist between the event time of interest and various longitudinal trends. In this paper, we consider a class of random-effects models known as shared parameter models that are particularly useful for jointly analysing such data; namely repeated measurements and event time data. Specific attention will be given to the longitudinal setting where the primary goal is to estimate and compare serial trends over time while adjusting for possible informative censoring due to patient dropout. Parametric and semi-parametric survival models for event times together with generalized linear or non-linear mixed-effects models for repeated measurements are proposed for jointly modelling serial outcome measures and event times. Methods of estimation are based on a generalized non-linear mixed-effects model that may be easily implemented using existing software. This approach allows for flexible modelling of both the distribution of event times and of the relationship of the longitudinal response variable to the event time of interest. The model and methods are illustrated using data from a multi-centre study of the effects of diet and blood pressure control on progression of renal disease, the modification of diet in renal disease study.

Original languageEnglish (US)
Pages (from-to)143-163
Number of pages21
JournalStatistics in Medicine
Volume25
Issue number1
DOIs
StatePublished - Jan 15 2006

Keywords

  • Accelerated failure time models
  • Generalized non-linear mixed-effects models
  • Laplace approximation
  • Non-ignorable dropout
  • Proportional hazards models

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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