Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells

Elsy Buitrago-Delgado, Kara Nordin, Anjali Rao, Lauren Geary, Carole LaBonne*

*Corresponding author for this work

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Neural crest cells, which are specific to vertebrates, arise in the ectoderm but can generate cell types that are typically categorized as mesodermal. This broad developmental potential persists past the time when most ectoderm-derived cells become lineage-restricted. The ability of neural crest to contribute mesodermal derivatives to the bauplan has raised questions about how this apparent gain in potential is achieved. Here, we describe shared molecular underpinnings of potency in neural crest and blastula cells. We show that in Xenopus, key neural crest regulatory factors are also expressed in blastula animal pole cells and promote pluripotency in both cell types. We suggest that neural crest cells may have evolved as a consequence of a subset of blastula cells retaining activity of the regulatory network underlying pluripotency.

Original languageEnglish (US)
Pages (from-to)1332-1335
Number of pages4
JournalScience
Volume348
Issue number6241
DOIs
StatePublished - Jun 19 2015

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Blastula
Neural Crest
Ectoderm
Cell Lineage
Xenopus
Vertebrates

ASJC Scopus subject areas

  • General

Cite this

Buitrago-Delgado, Elsy ; Nordin, Kara ; Rao, Anjali ; Geary, Lauren ; LaBonne, Carole. / Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells. In: Science. 2015 ; Vol. 348, No. 6241. pp. 1332-1335.
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Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells. / Buitrago-Delgado, Elsy; Nordin, Kara; Rao, Anjali; Geary, Lauren; LaBonne, Carole.

In: Science, Vol. 348, No. 6241, 19.06.2015, p. 1332-1335.

Research output: Contribution to journalArticle

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