Shear stress distributions on the membrane of endothelial cells using 3-D computational modeling with fluid-structure interactions

Dalin Tang*, Chun Yang, Shu Q. Liu

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

Fluid shear stress may play an important role in regulating cell activities and motility of growth factors in artery remodeling, atherosclerosis and re-stenosis process. 3-D computational models based on multi-cell experimental model are introduced and solved to quantify shear stress distributions on cell surfaces under physiological setting. Combined with experimental data, relationship between fluid shear stress and endothelial cell activities can be established. Cell geometry and membrane mechanical properties affect micro flow environment leading to considerable changes in shear stress distributions and various cell activities such as cell migration and activation of cell migration signaling mechanisms.

Original languageEnglish (US)
Pages (from-to)375-376
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Blood flow
  • Finite element
  • Fluid-structure interaction
  • Growth factor receptors
  • Shear stress

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Shear stress distributions on the membrane of endothelial cells using 3-D computational modeling with fluid-structure interactions'. Together they form a unique fingerprint.

Cite this