Short communication: High cellular iron levels are associated with increased HIV infection and replication

Hsiang Chun Chang, Marina Bayeva, Babafemi Taiwo, Frank J. Palella, Thomas J. Hope, Hossein Ardehali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

HIV is a pandemic disease, and many cellular and systemic factors are known to alter its infectivity and replication. Earlier studies had suggested that anemia is common in HIV-infected patients; however, higher iron was also observed in AIDS patients prior to the introduction of antiretroviral therapy (ART). Therefore, the relationship between iron and viral infection is not well delineated. To address this issue, we altered the levels of cellular iron in primary CD4+ T cells and showed that higher iron is associated with increased HIV infection and replication. In addition, HIV infection alone leads to increased cellular iron, and several ART drugs increase cellular iron independent of HIV infection. Finally, HIV infection is associated with increased serum iron in HIV-positive patients regardless of treatment with ART. These results establish a relationship between iron and HIV infection and suggest that iron homeostasis may be a viable therapeutic target for HIV.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalAIDS research and human retroviruses
Volume31
Issue number3
DOIs
StatePublished - Mar 1 2015

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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