Abstract
matrix presented An improved synthesis of protected cis- and trans-3-azido-L-proline and cis- and frans-4-azido-L- and -D-proline is reported. These compounds have been synthesized from the corresponding hydroxyproline precursors using diphenylphosphoryl azide under Mitsunobu conditions. Short, highly efficient syntheses of these precursors are described, based on a new lactone-opening reaction and p-nitrobenzoate hydrolysis under very mild conditions.
Original language | English (US) |
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Pages (from-to) | 2481-2484 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 16 |
DOIs | |
State | Published - Aug 9 2001 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry