TY - JOUR
T1 - Short, local duplications in eukaryotic genomes
AU - Thomas, Elizabeth E.
N1 - Funding Information:
EE Thomas thanks Nathan Srebro and Dana Pe’er for helpful comments. EE Thomas is funded by the NIGMS.
PY - 2005/12
Y1 - 2005/12
N2 - Short, local duplications lead to an increase in the local copy number of a 1-100 bp sequence motif. They are usually unstable and evolve rapidly. When they involve a functional sequence such as a transcription factor binding site or a protein-protein interaction domain, they can drive phenotypic diversity. Short, local duplications have been implicated in the dramatic morphological differences among different dog breeds, and in the differences in social structure between two sister species of voles. Several human diseases and disorders are also caused by this class of duplication, which encompasses microsatellites, minisatellites and doublets.
AB - Short, local duplications lead to an increase in the local copy number of a 1-100 bp sequence motif. They are usually unstable and evolve rapidly. When they involve a functional sequence such as a transcription factor binding site or a protein-protein interaction domain, they can drive phenotypic diversity. Short, local duplications have been implicated in the dramatic morphological differences among different dog breeds, and in the differences in social structure between two sister species of voles. Several human diseases and disorders are also caused by this class of duplication, which encompasses microsatellites, minisatellites and doublets.
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U2 - 10.1016/j.gde.2005.09.008
DO - 10.1016/j.gde.2005.09.008
M3 - Review article
C2 - 16214334
AN - SCOPUS:27444442357
SN - 0959-437X
VL - 15
SP - 640
EP - 644
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 6
ER -
