Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease

Tracy J. Doyle; Pierre Antoine Juge; Anna L. Peljto; Seoyeon Lee; Avram D. Walts; Anthony Joseph Esposito; Sergio Poli; Ritu Gill; Hiroto Hatabu; Mizuki Nishino; Paul F. Dellaripa; Michael E. Weinblatt; Nancy A. Shadick; M. Kristen Demoruelle; Jeffrey A. Sparks; Ivan O. Rosas; Benjamin Granger; Kevin D. Deane; Bruno Crestani; Paul J. Wolters; Philippe Dieudé; Joyce S. Lee

doi:10.1136/thorax-2023-220022

Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease

Tracy J. Doyle^*, Pierre Antoine Juge, Anna L. Peljto, Seoyeon Lee, Avram D. Walts, Anthony Joseph Esposito, Sergio Poli, Ritu Gill, Hiroto Hatabu, Mizuki Nishino, Paul F. Dellaripa, Michael E. Weinblatt, Nancy A. Shadick, M. Kristen Demoruelle, Jeffrey A. Sparks, Ivan O. Rosas, Benjamin Granger, Kevin D. Deane, Bruno Crestani, Paul J. WoltersPhilippe Dieudé, Joyce S. Lee

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.

Original language	English (US)
Pages (from-to)	182-185
Number of pages	4
Journal	Thorax
Volume	79
Issue number	2
DOIs	https://doi.org/10.1136/thorax-2023-220022
State	Published - Dec 7 2023

Funding

This work was supported by the National Institutes of Health [K23 HL119558, R03 HL148484 and R01 HL155522 to T.J.D.; F32 HL151132 to A.J.E.; R01CA203636, 5U01CA209414, 2R01HL111024, R01HL135142, and 1R01HL130974 to HH; P30 AR079369 to KDD and MKD; R01 AR077607, P30 AR070253, and P30 AR072577 to J.A.S; K23 HL138131 to JSL]; Nina Ireland Program for Lung Health to P.J.W. BRASS is funded by grants from Bristol Myers Squibb.

Keywords

interstitial fibrosis
rheumatoid lung disease

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1136/thorax-2023-220022

Cite this

Doyle, T. J., Juge, P. A., Peljto, A. L., Lee, S., Walts, A. D., Esposito, A. J., Poli, S., Gill, R., Hatabu, H., Nishino, M., Dellaripa, P. F., Weinblatt, M. E., Shadick, N. A., Demoruelle, M. K., Sparks, J. A., Rosas, I. O., Granger, B., Deane, K. D., Crestani, B., ... Lee, J. S. (2023). Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease. Thorax, 79(2), 182-185. https://doi.org/10.1136/thorax-2023-220022

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title = "Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease",

abstract = "Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.",

keywords = "interstitial fibrosis, rheumatoid lung disease",

author = "Doyle, {Tracy J.} and Juge, {Pierre Antoine} and Peljto, {Anna L.} and Seoyeon Lee and Walts, {Avram D.} and Esposito, {Anthony Joseph} and Sergio Poli and Ritu Gill and Hiroto Hatabu and Mizuki Nishino and Dellaripa, {Paul F.} and Weinblatt, {Michael E.} and Shadick, {Nancy A.} and Demoruelle, {M. Kristen} and Sparks, {Jeffrey A.} and Rosas, {Ivan O.} and Benjamin Granger and Deane, {Kevin D.} and Bruno Crestani and Wolters, {Paul J.} and Philippe Dieud{\'e} and Lee, {Joyce S.}",

year = "2023",

month = dec,

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doi = "10.1136/thorax-2023-220022",

language = "English (US)",

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Doyle, TJ, Juge, PA, Peljto, AL, Lee, S, Walts, AD, Esposito, AJ, Poli, S, Gill, R, Hatabu, H, Nishino, M, Dellaripa, PF, Weinblatt, ME, Shadick, NA, Demoruelle, MK, Sparks, JA, Rosas, IO, Granger, B, Deane, KD, Crestani, B, Wolters, PJ, Dieudé, P & Lee, JS 2023, 'Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease', Thorax, vol. 79, no. 2, pp. 182-185. https://doi.org/10.1136/thorax-2023-220022

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T1 - Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease

AU - Doyle, Tracy J.

AU - Juge, Pierre Antoine

AU - Peljto, Anna L.

AU - Lee, Seoyeon

AU - Walts, Avram D.

AU - Esposito, Anthony Joseph

AU - Poli, Sergio

AU - Gill, Ritu

AU - Hatabu, Hiroto

AU - Nishino, Mizuki

AU - Dellaripa, Paul F.

AU - Weinblatt, Michael E.

AU - Shadick, Nancy A.

AU - Demoruelle, M. Kristen

AU - Sparks, Jeffrey A.

AU - Rosas, Ivan O.

AU - Granger, Benjamin

AU - Deane, Kevin D.

AU - Crestani, Bruno

AU - Wolters, Paul J.

AU - Dieudé, Philippe

AU - Lee, Joyce S.

PY - 2023/12/7

Y1 - 2023/12/7

N2 - Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.

AB - Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.

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KW - rheumatoid lung disease

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ER -

Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease

Abstract

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Keywords

ASJC Scopus subject areas

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