Short sleep duration is associated with carotid intima-media thickness among men in the coronary artery risk development in young adults (CARDIA) study

Megan R. Sands*, Diane S. Lauderdale, Kiang Liu, Kristen L. Knutson, Karen A. Matthews, Charles B. Eaton, Crystal D. Linkletter, Eric B. Loucks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background and Purpose-Carotid intima-media thickness (CIMT) is a subclinical marker of cardiovascular disease. Recent studies suggest that shorter sleep duration is a risk factor for cardiovascular disease, but there is limited evidence regarding this association using high-quality, objective assessments of sleep. The aim of this study is to determine whether sleep duration is associated with CIMT. Methods-The study used an observational cohort consisting of 617 black and white middle-aged healthy participants (37-52 years; 58% female) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Multivariable-adjusted linear regression analyses were performed. Sleep duration was measured using wrist actigraphy monitors. CIMT was calculated using the average of 20 measurements of the mean common carotid, bulb, and internal CIMT, which was assessed using ultrasound images. Results-After adjusting for covariates, 1 hour of longer sleep duration was associated with 0.026 mm less CIMT among men (P=0.02; 95% CI,-0.047 to-0.005) and 0.001 mm less CIMT among women (P=0.91; 95% CI,-0.020 to 0.022). Segment-specific analyses indicated that the carotid bulb was a key driver of the observed association. Conclusions-Shorter objectively assessed sleep duration was associated with greater CIMT among men but not women.

Original languageEnglish (US)
Pages (from-to)2858-2864
Number of pages7
JournalStroke
Volume43
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • atherosclerosis
  • cardiovascular disease
  • carotid thickness
  • sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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