Short term effects of GnRH agonists on plasma fibrinolytic balance in patients with advanced prostate cancer

Mehmet Agirbasli*, Oytun A. Baykan, Ali Tekin, Feridun Sengor, Altug A. Cincin, Muzaffer Demir, Douglas E. Vaughan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Gonadotropin releasing hormone (GnRH) agonists are the cornerstone of metastatic prostate cancer treatment. Cardiovascular effects of GnRH agonists are unclear. In this study, we investigated the short term effects of GnRH agonists on plasma fibrinolytic parameters in patients with metastatic prostate cancer. Methods: Eleven patients (mean age 69.3 ± 6.5) with metastatic prostate cancer and a clinical indication for GnRH agonist therapy were selected. Plasma plasminogen activator inhibitor (PAI-1) antigen (Ag), tissue plasminogen activator (t-PA) Ag and thrombin-activatable fibrinolysis inhibitor (TAFI) activity levels were measured at baseline and at 4 weeks after the first dose of GnRH agonist, Goserelin Acetate (Zoladex®, subcutaneous administration, 10.8 mg). Results: Serum prostate specific antigen (PSA) levels significantly decreased from 36.6 ± 19.3 to 1.1 ± 0.3 ng/ml after Goserelin acetate treatment (P = 0.005). Significant changes occurred in the fibrinolytic parameters. GnRH agonists decreased plasma t-PA Ag levels (16.3 ± 4.9 vs. 12.2 ± 2.8 ng/ml, P = 0.047) and increased PAI-1/t-PA molar ratio (4.8 ± 3.6 vs. 6.6 ± 3.4, P = 0.16), on the other hand, plasma PAI-1 Ag (59.0 ± 48.5 vs. 56.4 ± 30.5 ng/ml, P = 0.8), and TAFI levels (130.6 ± 9.5 vs. 124.2 ± 26.5% activity, P = 0.3) did not change significantly. Conclusion: This study provides evidence that GnRH agonists may inhibit fibrinolytic system by decreasing t-PA levels.

Original languageEnglish (US)
Pages (from-to)172-174
Number of pages3
JournalJournal of Thrombosis and Thrombolysis
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2009

Keywords

  • GnRH agonists
  • PAI-1
  • Plasma fibrinolytic balance
  • t-PA
  • TAFI
  • Testosterone

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Short term effects of GnRH agonists on plasma fibrinolytic balance in patients with advanced prostate cancer'. Together they form a unique fingerprint.

Cite this