Shorter total sleep time is associated with lower CD4+/ CD8+ T cell ratios in virally suppressed men with HIV

Priya V. Borker; Bernard J. Macatangay; Joseph B. Margolick; Naresh M. Punjabi; Charles R. Rinaldo; Valentina Stosor; Joshua Hyong Jin Cho; Heather McKay; Sanjay R. Patel

doi:10.1093/sleepadvances/zpae001

Shorter total sleep time is associated with lower CD4+/ CD8+ T cell ratios in virally suppressed men with HIV

Priya V. Borker^*, Bernard J. Macatangay, Joseph B. Margolick, Naresh M. Punjabi, Charles R. Rinaldo, Valentina Stosor, Joshua Hyong Jin Cho, Heather McKay, Sanjay R. Patel

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Study Objectives: Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV. Methods: Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio. Results: Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm3 were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm3 (p = 0.05) and a 5.6% (p = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm3 (p = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (p = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations. Conclusions: Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.

Original language	English (US)
Article number	zpae001
Journal	SLEEP Advances
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/sleepadvances/zpae001
State	Published - 2024

Funding

This research was supported by the American Thoracic Society ASPIRE Fellowship program and the National Heart Lung and Blood Institute (NHLBI) grants HL082610 and HL143886. Additionally, data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS), now the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS was supported by the following grants: Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Data Analysis and Coordination Center (Gypsyamber D’Souza, Stephen Gange and Elizabeth Golub), U01-HL146193; Chicago Northwestern CRS (Steven Wolinsky), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo). The MWCCS is funded primarily by the NHLBI, with additional co-funding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR003098 (JHU ICTR), and UL1-TR001881 (UCLA CTSI). Financial disclosure: Dr. Punjabi has received research grant support from Resmed and Philips Respironics unrelated to the current study. Dr. Patel has received research grant support from Bayer, Philips Respironics, Respicardia, and Sommetrics unrelated to the current study and is a consultant for Apnimed, Bayer, NovaResp Technologies, Philips Respironics, and Powell Mansfield Inc. Dr. Stosor has received research grant support from Eli Lilly & Company and is a consultant for Diasorin, S.p.A. Nonfinancial disclosure: The authors have no other conflicts of interest to disclose. Role of the funders: The funding sources of the study had no role in study design, data collection, data analysis, data interpretation, writing of the manuscript, or decision to submit the manuscript for publication.

Keywords

HIV
T lymphocytes
total sleep time

ASJC Scopus subject areas

Behavioral Neuroscience
Clinical Neurology
Clinical Psychology
Neuropsychology and Physiological Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/sleepadvances/zpae001

Cite this

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title = "Shorter total sleep time is associated with lower CD4+/ CD8+ T cell ratios in virally suppressed men with HIV",

abstract = "Study Objectives: Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV. Methods: Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio. Results: Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm3 were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm3 (p = 0.05) and a 5.6% (p = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm3 (p = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (p = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations. Conclusions: Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.",

keywords = "HIV, T lymphocytes, total sleep time",

author = "Borker, {Priya V.} and Macatangay, {Bernard J.} and Margolick, {Joseph B.} and Punjabi, {Naresh M.} and Rinaldo, {Charles R.} and Valentina Stosor and Cho, {Joshua Hyong Jin} and Heather McKay and Patel, {Sanjay R.}",

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year = "2024",

doi = "10.1093/sleepadvances/zpae001",

language = "English (US)",

volume = "5",

journal = "SLEEP Advances",

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T1 - Shorter total sleep time is associated with lower CD4+/ CD8+ T cell ratios in virally suppressed men with HIV

AU - Borker, Priya V.

AU - Macatangay, Bernard J.

AU - Margolick, Joseph B.

AU - Punjabi, Naresh M.

AU - Rinaldo, Charles R.

AU - Stosor, Valentina

AU - Cho, Joshua Hyong Jin

AU - McKay, Heather

AU - Patel, Sanjay R.

PY - 2024

Y1 - 2024

N2 - Study Objectives: Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV. Methods: Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio. Results: Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm3 were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm3 (p = 0.05) and a 5.6% (p = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm3 (p = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (p = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations. Conclusions: Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.

AB - Study Objectives: Although poor sleep quality is associated with lower CD4+ T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV. Methods: Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+ and CD8+ T cell counts and the CD4+/CD8+ T cell ratio. Results: Overall, 289 men with mean (±SD) age 55.3 ± 11.3 years and mean CD4+ T cell count 730 ± 308 cells/mm3 were evaluated. Total sleep time (TST) was significantly associated with CD8+ but not CD4+ T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+ T cells/mm3 (p = 0.05) and a 5.6% (p = 0.0007) decline in CD4+/CD8+ T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+ T cells/mm3 (p = 0.02) and a 15.1% lower CD4+/CD8+ T cell ratio (p = 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations. Conclusions: Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.

KW - HIV

KW - T lymphocytes

KW - total sleep time

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Shorter total sleep time is associated with lower CD4+/ CD8+ T cell ratios in virally suppressed men with HIV

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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