Should all women with PCOS be treated for insulin resistance?

John C. Marshall*, Andrea Dunaif

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

PRO - A large majority of women with PCOS have insulin resistance, compensatory hyperinsulinemia with consequent reproductive and metabolic abnormalities. Metformin has been shown to be effective therapy and could be used more widely in obese adolescents with hyperandrogenemia, a forerunner of PCOS. CON - The severity of insulin resistance is highly variable in women with PCOS and may not be clinically relevant in milder phenotypes. Treatment should be directed at specific metabolic or reproductive problems and insulin sensitizing drugs are not always the optimum therapy.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalFertility and Sterility
Volume97
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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