Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles

Jun Sheng Zheng, Shan Yuan Zheng, Yi Bo Zhang, Bo Yu, Wenjie Zheng*, Fang Yang, Tianfeng Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume83
Issue number1
DOIs
StatePublished - Mar 1 2011

Keywords

  • Apoptosis
  • Cellular uptake
  • Nanoparticles
  • Selenium
  • Sialic acid

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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