Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles

Jun Sheng Zheng; Shan Yuan Zheng; Yi Bo Zhang; Bo Yu; Wenjie Zheng; Fang Yang; Tianfeng Chen

doi:10.1016/j.colsurfb.2010.11.023

Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles

Jun Sheng Zheng, Shan Yuan Zheng, Yi Bo Zhang, Bo Yu, Wenjie Zheng^*, Fang Yang, Tianfeng Chen

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	Colloids and Surfaces B: Biointerfaces
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2010.11.023
State	Published - Mar 1 2011

Funding

This work was supported by Natural Science Foundation of China and Guangdong Province , Key Project of Science and Technology Department of Guangdong Province , the Fundamental Research Funds for the Central Universities and China Postdoctoral Science Foundation .

Keywords

Apoptosis
Cellular uptake
Nanoparticles
Selenium
Sialic acid

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.colsurfb.2010.11.023

Cite this

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title = "Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles",

abstract = "A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.",

keywords = "Apoptosis, Cellular uptake, Nanoparticles, Selenium, Sialic acid",

author = "Zheng, {Jun Sheng} and Zheng, {Shan Yuan} and Zhang, {Yi Bo} and Bo Yu and Wenjie Zheng and Fang Yang and Tianfeng Chen",

note = "Funding Information: This work was supported by Natural Science Foundation of China and Guangdong Province , Key Project of Science and Technology Department of Guangdong Province , the Fundamental Research Funds for the Central Universities and China Postdoctoral Science Foundation .",

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AU - Zheng, Jun Sheng

AU - Zheng, Shan Yuan

AU - Zhang, Yi Bo

AU - Yu, Bo

AU - Zheng, Wenjie

AU - Yang, Fang

AU - Chen, Tianfeng

N1 - Funding Information: This work was supported by Natural Science Foundation of China and Guangdong Province , Key Project of Science and Technology Department of Guangdong Province , the Fundamental Research Funds for the Central Universities and China Postdoctoral Science Foundation .

PY - 2011/3/1

Y1 - 2011/3/1

N2 - A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.

AB - A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.

KW - Apoptosis

KW - Cellular uptake

KW - Nanoparticles

KW - Selenium

KW - Sialic acid

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JO - Colloids and Surfaces B: Biointerfaces

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Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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