Abstract
A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.
Original language | English (US) |
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Pages (from-to) | 183-187 |
Number of pages | 5 |
Journal | Colloids and Surfaces B: Biointerfaces |
Volume | 83 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 2011 |
Funding
This work was supported by Natural Science Foundation of China and Guangdong Province , Key Project of Science and Technology Department of Guangdong Province , the Fundamental Research Funds for the Central Universities and China Postdoctoral Science Foundation .
Keywords
- Apoptosis
- Cellular uptake
- Nanoparticles
- Selenium
- Sialic acid
ASJC Scopus subject areas
- Biotechnology
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry