Signal-oriented pathway analyses reveal a signaling complex as a synthetic lethal target for p53 mutations

Keyphrases

• Path Analysis 100%
• Transcriptomics 100%
• Signaling Complex 100%
• Synthetic Lethal 100%
• TP53 mutation 100%
• Signal Base 100%
• Somatic Gene Alteration 100%
• In Cancer 66%
• PTK2 66%
• YWHAZ 66%
• Cancer Types 33%
• Cell Proliferation 33%
• Precision Medicine 33%
• Computational Framework 33%
• Therapeutic Target 33%
• Knockdown 33%
• Epithelial-mesenchymal Transition 33%
• Therapeutic Strategies 33%
• Cancer Cells 33%
• All Cancer 33%
• Tumor Protein p53 (TP53) 33%
• Mutant p53 33%
• Oncogenic Process 33%
• Multiple Tumors 33%
• Cancer Pathways 33%
• Graph-based 33%
• MED1 33%
• Colony Formation 33%
• Bipartite Graph 33%
• Functional Modules 33%
• Merging Method 33%
• Discovery Algorithm 33%
• Computational Evaluation 33%
• Oncogenic Phenotype 33%
• K-path 33%
• Anchor-free 33%
• Pathway Discovery 33%
• Module Discovery 33%

Biochemistry, Genetics and Molecular Biology

• Transcriptomics 100%
• P53 100%
• PTK2 66%
• Carcinogenesis 66%
• MED1 33%
• Cancer Cell 33%
• Cell Proliferation 33%
• Mesenchymal-Epithelial Transition 33%
• Colony Formation 33%