Signal transduction pathways in critical illness and injury

Timothy T. Cornell*, Waseem Ostwani, Lei Sun, Steven L. Kunkel, Thomas P. Shanley

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Cells respond to environmental stimuli using an elaborate process to propagate and amplify a signal from the cell surface to the nucleus leading to initiation of gene induction in a process termed “signal transduction”. The NFκB and MAPK pathways are two important pathways in the cellular responses during critical illness. Both pathways are composed of a series of kinases that utilize phosphorylation to activate downstream kinases. Once activated these pathways must be deactivated in order to reestablish homeostasis usually by a phosphatase. Additionally, intracellular inhibitors and epigenetic processes are important in regulating the activation of signal pathways.

Original languageEnglish (US)
Title of host publicationPediatric Critical Care Medicine
Subtitle of host publicationVolume 1: Care of the Critically Ill or Injured Child, Second Edition
PublisherSpringer-Verlag London Ltd
Number of pages14
ISBN (Electronic)9781447163626
ISBN (Print)9781447163619
StatePublished - Jan 1 2014


  • Epigenetics
  • Histone modifications
  • MAP kinase pathways
  • MicroRNA
  • NFκB
  • Phosphatases
  • Regulators of signal transduction
  • Signal transduction

ASJC Scopus subject areas

  • General Medicine


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