Signal transduction pathways in critical illness and injury

Timothy T. Cornell; Waseem Ostwani; Lei Sun; Steven L. Kunkel; Thomas P. Shanley

doi:10.1007/978-1-4471-6362-6_21

Signal transduction pathways in critical illness and injury

Timothy T. Cornell^*, Waseem Ostwani, Lei Sun, Steven L. Kunkel, Thomas P. Shanley

^*Corresponding author for this work

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cells respond to environmental stimuli using an elaborate process to propagate and amplify a signal from the cell surface to the nucleus leading to initiation of gene induction in a process termed “signal transduction”. The NFκB and MAPK pathways are two important pathways in the cellular responses during critical illness. Both pathways are composed of a series of kinases that utilize phosphorylation to activate downstream kinases. Once activated these pathways must be deactivated in order to reestablish homeostasis usually by a phosphatase. Additionally, intracellular inhibitors and epigenetic processes are important in regulating the activation of signal pathways.

Original language	English (US)
Title of host publication	Pediatric Critical Care Medicine
Subtitle of host publication	Volume 1: Care of the Critically Ill or Injured Child, Second Edition
Publisher	Springer-Verlag London Ltd
Pages	217-230
Number of pages	14
ISBN (Electronic)	9781447163626
ISBN (Print)	9781447163619
DOIs	https://doi.org/10.1007/978-1-4471-6362-6_21
State	Published - Jan 1 2014

Keywords

Epigenetics
Histone modifications
MAP kinase pathways
MicroRNA
NFκB
Phosphatases
Regulators of signal transduction
Signal transduction

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4471-6362-6_21

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abstract = "Cells respond to environmental stimuli using an elaborate process to propagate and amplify a signal from the cell surface to the nucleus leading to initiation of gene induction in a process termed “signal transduction”. The NFκB and MAPK pathways are two important pathways in the cellular responses during critical illness. Both pathways are composed of a series of kinases that utilize phosphorylation to activate downstream kinases. Once activated these pathways must be deactivated in order to reestablish homeostasis usually by a phosphatase. Additionally, intracellular inhibitors and epigenetic processes are important in regulating the activation of signal pathways.",

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AU - Cornell, Timothy T.

AU - Ostwani, Waseem

AU - Sun, Lei

AU - Kunkel, Steven L.

AU - Shanley, Thomas P.

N1 - Publisher Copyright: © Springer-Verlag London 2014.

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Y1 - 2014/1/1

N2 - Cells respond to environmental stimuli using an elaborate process to propagate and amplify a signal from the cell surface to the nucleus leading to initiation of gene induction in a process termed “signal transduction”. The NFκB and MAPK pathways are two important pathways in the cellular responses during critical illness. Both pathways are composed of a series of kinases that utilize phosphorylation to activate downstream kinases. Once activated these pathways must be deactivated in order to reestablish homeostasis usually by a phosphatase. Additionally, intracellular inhibitors and epigenetic processes are important in regulating the activation of signal pathways.

AB - Cells respond to environmental stimuli using an elaborate process to propagate and amplify a signal from the cell surface to the nucleus leading to initiation of gene induction in a process termed “signal transduction”. The NFκB and MAPK pathways are two important pathways in the cellular responses during critical illness. Both pathways are composed of a series of kinases that utilize phosphorylation to activate downstream kinases. Once activated these pathways must be deactivated in order to reestablish homeostasis usually by a phosphatase. Additionally, intracellular inhibitors and epigenetic processes are important in regulating the activation of signal pathways.

KW - Epigenetics

KW - Histone modifications

KW - MAP kinase pathways

KW - MicroRNA

KW - NFκB

KW - Phosphatases

KW - Regulators of signal transduction

KW - Signal transduction

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BT - Pediatric Critical Care Medicine

PB - Springer-Verlag London Ltd

ER -

Signal transduction pathways in critical illness and injury

Abstract

Keywords

ASJC Scopus subject areas

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