Signaling by Type I Interferons in Immune Cells: Disease Consequences

Markella Zannikou; Eleanor N. Fish; Leonidas C. Platanias

doi:10.3390/cancers16081600

Signaling by Type I Interferons in Immune Cells: Disease Consequences

Markella Zannikou, Eleanor N. Fish, Leonidas C. Platanias^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

Abstract

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.

Original language	English (US)
Article number	1600
Journal	Cancers
Volume	16
Issue number	8
DOIs	https://doi.org/10.3390/cancers16081600
State	Published - Apr 2024

Funding

The research of LCP is supported by grant R01-CA77816 by the NIH.

Keywords

B cells
NK cells
T cell
cancer
dendritic cell
immune cells
interferons
macrophage
neutrophils
signaling
tumor microenvironment

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers16081600

Cite this

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title = "Signaling by Type I Interferons in Immune Cells: Disease Consequences",

abstract = "This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.",

keywords = "B cells, NK cells, T cell, cancer, dendritic cell, immune cells, interferons, macrophage, neutrophils, signaling, tumor microenvironment",

author = "Markella Zannikou and Fish, {Eleanor N.} and Platanias, {Leonidas C.}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = apr,

doi = "10.3390/cancers16081600",

language = "English (US)",

volume = "16",

journal = "Cancers",

issn = "2072-6694",

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T1 - Signaling by Type I Interferons in Immune Cells

T2 - Disease Consequences

AU - Zannikou, Markella

AU - Fish, Eleanor N.

AU - Platanias, Leonidas C.

PY - 2024/4

Y1 - 2024/4

N2 - This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.

AB - This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.

KW - B cells

KW - NK cells

KW - T cell

KW - cancer

KW - dendritic cell

KW - immune cells

KW - interferons

KW - macrophage

KW - neutrophils

KW - signaling

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85191454701&partnerID=8YFLogxK

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U2 - 10.3390/cancers16081600

DO - 10.3390/cancers16081600

M3 - Review article

C2 - 38672681

AN - SCOPUS:85191454701

SN - 2072-6694

VL - 16

JO - Cancers

JF - Cancers

IS - 8

M1 - 1600

ER -

Signaling by Type I Interferons in Immune Cells: Disease Consequences

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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