Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2

Keyphrases

• EGF Receptor 100%
• Matrix Metalloproteinases 100%
• Matrix metalloproteinase-2 (MMP-2) 100%
• Gelatinase 100%
• Lung Morphogenesis 100%
• Lung 87%
• Epidermal Growth Factor Receptor 87%
• Alveolization 37%
• Epithelial-mesenchymal Interaction 25%
• Downstream Targets 12%
• Signaling Factors 12%
• Lung Development 12%
• Healthy Lung 12%
• Low Expression 12%
• At Birth 12%
• Morphogenesis 12%
• Extracellular Signaling 12%
• Branching Morphogenesis 12%
• Aberrant Expression 12%
• Proteolysis 12%
• Lung Fibroblasts 12%
• EGFR Signaling 12%
• Mesenchyme 12%
• MMP14 12%
• In Situ Zymography 12%
• Gelatinolytic Activity 12%
• Lung Maturation 12%
• Zymography 12%
• Abnormal Branching 12%
• Active Matrix 12%

Biochemistry, Genetics and Molecular Biology

• Morphogenesis 100%
• Epidermal Growth Factor Receptor 100%
• Matrix Metalloproteinase 100%
• MMP2 100%
• Gelatinase A 100%
• Zymography 25%
• Wild Type 12%
• MMP14 12%
• Enzyme 12%
• Lung Development 12%
• Branching Morphogenesis 12%
• Fetus Lung Maturation 12%
• Mesenchyme 12%
• Messenger RNA 12%
• Fibroblast 12%
• Proteolysis 12%