Signs and symptoms of “asymptomatic” hiv-1 infection in homosexual men

Donald R. Hoover*, Alfred J. Saah, Helena Bacellar, Robert Murphy, Barbara Visscher, Roger Anderson, Richard A. Kaslow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

We investigated the long-term health effects of HIV-1 infection in homosexual men not close to developing AIDS by comparing 916 HIV-1-seropositive (SP) men at least 1.67-3.67 years prior to a clinical AIDS diagnosis to 2, 161 HIV-1-seronegative (SN) controls. The SP group reported a higher total of 12 distinct symptoms (fatigue, shortness of breath, night sweats, rash, cough, diarrhea, headache, thrush, skin discoloration, fever, weight loss, and sore throat/mouth) than did the SN group (p <0.0001), corresponding to at least 5.6 more days/year of such symptoms. The SP group had lower body mass index (p <0.0001) and lower hemoglobin (p <0.0001). The SP group was more depressed, as measured by CES-D score (p = 0.047), before knowledge of one's serostatus was likely, and became even further depressed (p = 0.038 for increase in depression) after the HIV-1 serostatus test was accessible to high-risk groups. These associations remained unchanged in multivariate models, incorporating other covariates.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume6
Issue number1
StatePublished - Jan 1993

Keywords

  • Chronic impact
  • Depression
  • HIV-1
  • Health status
  • Pre-AIDS
  • Symptoms

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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