TY - JOUR
T1 - Signs and symptoms of “asymptomatic” hiv-1 infection in homosexual men
AU - Hoover, Donald R.
AU - Saah, Alfred J.
AU - Bacellar, Helena
AU - Murphy, Robert
AU - Visscher, Barbara
AU - Anderson, Roger
AU - Kaslow, Richard A.
PY - 1993/1
Y1 - 1993/1
N2 - We investigated the long-term health effects of HIV-1 infection in homosexual men not close to developing AIDS by comparing 916 HIV-1-seropositive (SP) men at least 1.67-3.67 years prior to a clinical AIDS diagnosis to 2, 161 HIV-1-seronegative (SN) controls. The SP group reported a higher total of 12 distinct symptoms (fatigue, shortness of breath, night sweats, rash, cough, diarrhea, headache, thrush, skin discoloration, fever, weight loss, and sore throat/mouth) than did the SN group (p <0.0001), corresponding to at least 5.6 more days/year of such symptoms. The SP group had lower body mass index (p <0.0001) and lower hemoglobin (p <0.0001). The SP group was more depressed, as measured by CES-D score (p = 0.047), before knowledge of one's serostatus was likely, and became even further depressed (p = 0.038 for increase in depression) after the HIV-1 serostatus test was accessible to high-risk groups. These associations remained unchanged in multivariate models, incorporating other covariates.
AB - We investigated the long-term health effects of HIV-1 infection in homosexual men not close to developing AIDS by comparing 916 HIV-1-seropositive (SP) men at least 1.67-3.67 years prior to a clinical AIDS diagnosis to 2, 161 HIV-1-seronegative (SN) controls. The SP group reported a higher total of 12 distinct symptoms (fatigue, shortness of breath, night sweats, rash, cough, diarrhea, headache, thrush, skin discoloration, fever, weight loss, and sore throat/mouth) than did the SN group (p <0.0001), corresponding to at least 5.6 more days/year of such symptoms. The SP group had lower body mass index (p <0.0001) and lower hemoglobin (p <0.0001). The SP group was more depressed, as measured by CES-D score (p = 0.047), before knowledge of one's serostatus was likely, and became even further depressed (p = 0.038 for increase in depression) after the HIV-1 serostatus test was accessible to high-risk groups. These associations remained unchanged in multivariate models, incorporating other covariates.
KW - Chronic impact
KW - Depression
KW - HIV-1
KW - Health status
KW - Pre-AIDS
KW - Symptoms
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M3 - Article
C2 - 8417176
AN - SCOPUS:0027395739
VL - 6
SP - 66
EP - 71
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
SN - 1525-4135
IS - 1
ER -
