Silence from within: Endogenous siRNAs and miRNAs

Erik J. Sontheimer*, Richard W. Carthew

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

254 Scopus citations


Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
Issue number1
StatePublished - Jul 15 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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