Silence from within: Endogenous siRNAs and miRNAs

Erik J. Sontheimer; Richard W. Carthew

doi:10.1016/j.cell.2005.06.030

Silence from within: Endogenous siRNAs and miRNAs

Erik J. Sontheimer^*, Richard W. Carthew

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Short survey › peer-review

259 Scopus citations

Abstract

Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Cell
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2005.06.030
State	Published - Jul 15 2005

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2005.06.030

Cite this

@article{7d3e3938528946d69ce9e50dbdfac75e,

title = "Silence from within: Endogenous siRNAs and miRNAs",

abstract = "Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.",

author = "Sontheimer, {Erik J.} and Carthew, {Richard W.}",

year = "2005",

month = jul,

day = "15",

doi = "10.1016/j.cell.2005.06.030",

language = "English (US)",

volume = "122",

pages = "9--12",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Silence from within

T2 - Endogenous siRNAs and miRNAs

AU - Sontheimer, Erik J.

AU - Carthew, Richard W.

PY - 2005/7/15

Y1 - 2005/7/15

N2 - Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

AB - Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

UR - http://www.scopus.com/inward/record.url?scp=22144437679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144437679&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2005.06.030

DO - 10.1016/j.cell.2005.06.030

M3 - Short survey

C2 - 16009127

AN - SCOPUS:22144437679

SN - 0092-8674

VL - 122

SP - 9

EP - 12

JO - Cell

JF - Cell

IS - 1

ER -

Silence from within: Endogenous siRNAs and miRNAs

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this