Silence from within: Endogenous siRNAs and miRNAs

Erik J. Sontheimer*, Richard W. Carthew

*Corresponding author for this work

Research output: Contribution to journalShort survey

220 Citations (Scopus)

Abstract

Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalCell
Volume122
Issue number1
DOIs
StatePublished - Jul 15 2005

Fingerprint

RNA Interference
MicroRNAs
Genes
RNA
Eukaryotic Cells
Pathogens
Bioinformatics
Computational Biology
Gene expression
Vertebrates
Down-Regulation
Gene Expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sontheimer, Erik J. ; Carthew, Richard W. / Silence from within : Endogenous siRNAs and miRNAs. In: Cell. 2005 ; Vol. 122, No. 1. pp. 9-12.
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Silence from within : Endogenous siRNAs and miRNAs. / Sontheimer, Erik J.; Carthew, Richard W.

In: Cell, Vol. 122, No. 1, 15.07.2005, p. 9-12.

Research output: Contribution to journalShort survey

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