Silencing STATs: Lessons from paramyxovirus interferon evasion

Curt M. Horvath*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

The signal transducer and activator of transcription (STAT) family proteins are essential mediators of cytokine and growth factor functions. The interferon (IFN) family of cytokines is well known as modulators of both innate and adaptive anti-microbial immunity. In response to the evolutionary struggle between host and pathogen, many viruses have developed strategies to bypass the IFN antiviral system. Uniquely, the paramyxoviruses have developed the ability to efficiently inactivate STAT protein function, in many cases using a single virus-encoded protein called 'V'. The V protein plays a central role in STAT inhibition, but mechanistic studies have revealed great diversity in V-dependent STAT signaling evasion among paramyxovirus species. These examples of IFN evasion by STAT protein inactivation can help define targets for antiviral drug design or improving vaccine regimens. Moreover, understanding these STAT inhibition mechanisms are likely to reveal strategic options for the design of STAT-directed therapeutics for treatment of diseases characterized by cytokine hyperactivity.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalCytokine and Growth Factor Reviews
Volume15
Issue number2-3
DOIs
StatePublished - 2004

Keywords

  • Antiviral
  • Immune evasion
  • Interferon
  • Paramyxovirus
  • STAT protein

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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