Silicon-based aromatic transferring linkers for traceless solid-phase synthesis of aryl-, polyaryl-, and heteroaryl-containing compounds

Y. Lee, R. B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A number of arylsilane-based linkers are prepared for traceless solid-phase synthesis. General methodologies for introduction of the silyl group and various functional groups to aromatic, polyaromatic, and heteroaromatic rings are developed. Also, broad utilities of the linkers are demonstrated by on-resin preparation of small organic molecules and subsequent cleavage of the products either by protiodesilylation (TFA) or ipso-substitution (Br2).

Original languageEnglish (US)
Pages (from-to)5339-5352
Number of pages14
JournalTetrahedron
Volume57
Issue number25
DOIs
StatePublished - Jun 18 2001

Keywords

  • Aromatic
  • Heteroaromatic compounds
  • Polyaromatic
  • Traceless solid-phase synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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