Silver nanoparticle - Oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties

Jae Seung Lee, Abigail K.R. Lytton-Jean, Sarah J. Hurst, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

435 Scopus citations


We report a new strategy for preparing silver nanoparticle-oligonucleotide conjugates that are based upon DNA with cyclic disulfide-anchoring groups. These particles are extremely stable and can withstand NaCI concentrations up to 1.0 M. When silver nanoparticles functionalized with complementary sequences are combined, they assemble to form DNA-linked nanoparticle networks. This assembly process is reversible with heating and is associated with a red shifting of the particle surface plasmon resonance and a concomitant color change from yellow to pale red. Analogous to the oligonucleotide-functionalized gold nanoparticles, these particles also exhibit highly cooperative binding properties with extremely sharp melting transitions. This work is an important step toward using silver nanoparticle-oligonucleotide conjugates for a variety of purposes, including molecular diagnostic labels, synthons in programmable materials synthesis approaches, and functional components for nanoelectronic and plasmonic devices.

Original languageEnglish (US)
Pages (from-to)2112-2115
Number of pages4
JournalNano letters
Issue number7
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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