Silver/hydroxyapatite composite coatings on porous titanium surfaces by sol-gel method

Jie Qu, Xiong Lu*, Dan Li, Ding Yonghui, Yang Leng, Jie Weng, Shuxin Qu, Bo Feng, Fumio Watari

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Hydroxyapatite (HA) coatings loaded with nanosilver particles is an attractive method to impart the HA coating with antibacterial properties. Producing Ag/HA coatings on porous Ti substrates have been an arduous job since commonly used line-of-sight techniques are not able to deposit uniform coatings on the inner pore surfaces of the porous Ti. In this study, porous Ti scaffolds with high porosity and interconnected structures were prepared by polymer impregnating method. A sol-gel process was used to produce uniform Ag/HA composite coatings on the surfaces of porous Ti substrates. Ca(NO 3)2 ·4H2O and P2O 5 in an ethyl alcohol based system was selected to prepare the sol, which ensured the homogeneous distribution of Ag in the sol. The characterization revealed that silver particles uniformly distributed in the coatings without agglomeration. High antibacterial ratio (>95%), against E. coli and S. albus was expressed by the silver-containing coatings (Ag/HA 0.8 and 1.6 wt %). The biocompatibility of the Ag/HA 0.8 surfaces was as good as that of pure HA surface, as revealed by culturing osteoblasts on them. The results indicated that Ag/HA 0.8 had the good balance between the biocompatibility and antibacterial properties of the coatings.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume97 B
Issue number1
StatePublished - Apr 2011


  • antibacterial properties
  • biocompatibility
  • hydroxyapatite
  • porous coatings
  • silver
  • sol-gel

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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