Simple, miniaturized biosensors for wireless mapping of thermoregulatory responses

Seyong Oh*, Jae Young Yoo, Woo Youl Maeng, Seonggwang Yoo, Tianyu Yang, Susan Marie Slattery, Sara Pessano, Emily Chang, Hyoyoung Jeong, Jihye Kim, Hak Young Ahn, Yeongdo Kim, Joohee Kim, Shuai Xu, Debra E Weese-Mayer, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Temperature is the most commonly collected vital sign in all of clinical medicine; it plays a critical role in care decisions related to topics ranging from infection to inflammation, sleep, and fertility. Most assessments of body temperature occur at isolated anatomical locations (e.g. axilla, rectum, temporal artery, or oral cavity). Even this relatively primitive mode for monitoring can be challenging with vulnerable patient populations due to physical encumbrances and artifacts associated with the sizes, weights, shapes and mechanical properties of the sensors and, for continuous monitoring, their hard-wired interfaces to data collection units. Here, we introduce a simple, miniaturized, lightweight sensor as a wireless alternative, designed to address demanding applications such as those related to the care of neonates in high ambient humidity environments with radiant heating found in incubators in intensive care units. Such devices can be deployed onto specific anatomical locations of premature infants for homeostatic assessments. The estimated core body temperature aligns, to within 0.05 °C, with clinical grade, wired sensors, consistent with regulatory medical device requirements. Time-synchronized, multi-device operation across multiple body locations supports continuous, full-body measurements of spatio-temporal variations in temperature and additional modes of determining tissue health status in the context of sepsis detection and various environmental exposures. In addition to thermal sensing, these same devices support measurements of a range of other essential vital signs derived from thermo-mechanical coupling to the skin, for applications ranging from neonatal and infant care to sleep medicine and even pulmonary medicine.

Original languageEnglish (US)
Article number115545
JournalBiosensors and Bioelectronics
StatePublished - Oct 1 2023


  • Bioelectronics
  • Health monitoring
  • Thermoregulatory responses
  • Wireless sensors

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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