Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons

Martha C. Bohn*, John A. Kessler, Joshua E. Adler, Keith Markey, Menek Goldstein, Ira B. Black

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro9. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity to both SP and TOH was present in the majority of principal neurons. This observation suggests that principal sympathetic neurons can express simultaneously both the noradrenergic and SP-peptidergic phenotypes.

Original languageEnglish (US)
Pages (from-to)378-381
Number of pages4
JournalBrain research
Volume298
Issue number2
DOIs
StatePublished - Apr 30 1984

Keywords

  • immunocytochemistry
  • neuronal plasticity
  • neurotransmitters
  • phenotypic expression
  • substance P
  • sympathetic neurons
  • tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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