Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons

Martha C. Bohn; John A. Kessler; Joshua E. Adler; Keith Markey; Menek Goldstein; Ira B. Black

doi:10.1016/0006-8993(84)91442-2

Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons

Martha C. Bohn^*, John A. Kessler, Joshua E. Adler, Keith Markey, Menek Goldstein, Ira B. Black

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro⁹. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity to both SP and TOH was present in the majority of principal neurons. This observation suggests that principal sympathetic neurons can express simultaneously both the noradrenergic and SP-peptidergic phenotypes.

Original language	English (US)
Pages (from-to)	378-381
Number of pages	4
Journal	Brain research
Volume	298
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91442-2
State	Published - Apr 30 1984

Keywords

immunocytochemistry
neuronal plasticity
neurotransmitters
phenotypic expression
substance P
sympathetic neurons
tyrosine hydroxylase

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)91442-2

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@article{8bfd569cc8864ff9965bf7a97965ec4e,

title = "Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons",

abstract = "We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro9. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity to both SP and TOH was present in the majority of principal neurons. This observation suggests that principal sympathetic neurons can express simultaneously both the noradrenergic and SP-peptidergic phenotypes.",

keywords = "immunocytochemistry, neuronal plasticity, neurotransmitters, phenotypic expression, substance P, sympathetic neurons, tyrosine hydroxylase",

author = "Bohn, {Martha C.} and Kessler, {John A.} and Adler, {Joshua E.} and Keith Markey and Menek Goldstein and Black, {Ira B.}",

note = "Funding Information: This work was supported by NIH Grants NS 18420, NS 06400, NS 17285, NS 10259 and HD 12108, a Research Career Development Award to M.C.B., Irma T. Hirschl Career Scientist and George Cotzias Awards to J.A.K. and by grants from the Familial Dysautonomia Foundation. The authors are very grateful for the excellent technical assistance of Ms. Dana Straka, Mrs. Theresa Markey, Mrs. Robyn Walsh, Mrs. Bettye Mayer, Ms. Elise Grossman and Mrs. Frances Miragliotta.",

year = "1984",

month = apr,

day = "30",

doi = "10.1016/0006-8993(84)91442-2",

language = "English (US)",

volume = "298",

pages = "378--381",

journal = "Brain research",

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number = "2",

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T1 - Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons

AU - Bohn, Martha C.

AU - Kessler, John A.

AU - Adler, Joshua E.

AU - Markey, Keith

AU - Goldstein, Menek

AU - Black, Ira B.

N1 - Funding Information: This work was supported by NIH Grants NS 18420, NS 06400, NS 17285, NS 10259 and HD 12108, a Research Career Development Award to M.C.B., Irma T. Hirschl Career Scientist and George Cotzias Awards to J.A.K. and by grants from the Familial Dysautonomia Foundation. The authors are very grateful for the excellent technical assistance of Ms. Dana Straka, Mrs. Theresa Markey, Mrs. Robyn Walsh, Mrs. Bettye Mayer, Ms. Elise Grossman and Mrs. Frances Miragliotta.

PY - 1984/4/30

Y1 - 1984/4/30

N2 - We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro9. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity to both SP and TOH was present in the majority of principal neurons. This observation suggests that principal sympathetic neurons can express simultaneously both the noradrenergic and SP-peptidergic phenotypes.

AB - We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro9. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity to both SP and TOH was present in the majority of principal neurons. This observation suggests that principal sympathetic neurons can express simultaneously both the noradrenergic and SP-peptidergic phenotypes.

KW - immunocytochemistry

KW - neuronal plasticity

KW - neurotransmitters

KW - phenotypic expression

KW - substance P

KW - sympathetic neurons

KW - tyrosine hydroxylase

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AN - SCOPUS:0021141645

SN - 0006-8993

VL - 298

SP - 378

EP - 381

JO - Brain research

JF - Brain research

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ER -

Simultaneous expression of the SP-peptidergic and noradrenergic phenotypes in rat sympathetic neurons

Abstract

Keywords

ASJC Scopus subject areas

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