Simultaneous in vivo imaging of dual molecular contrasts in the retina with multimodal photoacoustic ophthalmoscopy

Shuliang Jiao*, Hao F. Zhang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective vs. exacerbate) in the RPE in the aging process. We successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases.

Original languageEnglish (US)
Title of host publicationBiomedical Optics, BIOMED 2012
PublisherOptical Society of America (OSA)
PagesBM2B.6
ISBN (Print)9781557529428
DOIs
StatePublished - Jan 1 2012
EventBiomedical Optics, BIOMED 2012 - Miami, FL, United States
Duration: Apr 28 2012May 2 2012

Publication series

NameBiomedical Optics, BIOMED 2012

Other

OtherBiomedical Optics, BIOMED 2012
CountryUnited States
CityMiami, FL
Period4/28/125/2/12

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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