TY - JOUR
T1 - Simultaneous measurement of angular and spectral properties of light scattering for early cancer detection
AU - Liu, Yang
AU - Kim, Young L.
AU - Wali, Ramesh K.
AU - Roy, Hemant K.
AU - Goldberg, Micheal J.
AU - Kromine, Alexei K.
AU - Chen, Kun
AU - Backman, Vadim
PY - 2003
Y1 - 2003
N2 - A novel instrument has been developed for the angular, spectral, azimuthal and polarization measurements of the light backscattering by living biological tissues. These measurements provide the most comprehensive quantitative information about the light scattering and allow obtaining unique quantitative information about the microarchitecture of living cells and tissues. We have shown the potential of this technique to characterize and diagnose very early premalignant changes in the epithelia, for which no histological or molecular markers has yet been established. Using this technique in our studies with a rodent model of colon carcinogenesis we obtained several parameters diagnostically significant for the detection of precancerous changes, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue microarchitecture, and the average roundness of subcellular structures.
AB - A novel instrument has been developed for the angular, spectral, azimuthal and polarization measurements of the light backscattering by living biological tissues. These measurements provide the most comprehensive quantitative information about the light scattering and allow obtaining unique quantitative information about the microarchitecture of living cells and tissues. We have shown the potential of this technique to characterize and diagnose very early premalignant changes in the epithelia, for which no histological or molecular markers has yet been established. Using this technique in our studies with a rodent model of colon carcinogenesis we obtained several parameters diagnostically significant for the detection of precancerous changes, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue microarchitecture, and the average roundness of subcellular structures.
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M3 - Conference article
AN - SCOPUS:8744278922
SN - 1094-5695
VL - 88
SP - 98
EP - 99
JO - OSA Trends in Optics and Photonics Series
JF - OSA Trends in Optics and Photonics Series
T2 - Conference on Lasers and Electro-Optics (CLEO); Postconference Digest
Y2 - 1 June 2003 through 6 June 2003
ER -
