Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection

Yang Liu; Young L. Kim; Ramesh K. Wali; Hemant K. Roy; Micheal J. Goldberg; Alexei K. Kromine; Kun Chen; Vadim Backman

Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection

Yang Liu^*, Young L. Kim, Ramesh K. Wali, Hemant K. Roy, Micheal J. Goldberg, Alexei K. Kromine, Kun Chen, Vadim Backman

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A novel instrument has been developed for the angular, spectral, azimuthal and polarization measurements of the light backscattering by living biological tissues. These measurements provide the most comprehensive quantitative information about the light scattering and allow obtaining unique quantitative information about the microarchitecture of living cells and tissues. We have shown the potential of this technique to characterize and diagnose very early premalignant changes in the epithelia, for which no histological or molecular markers has yet been established. Using this technique in our studies with a rodent model of colon carcinogenesis we obtained several parameters diagnostically significant for the detection of precancerous changes, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue microarchitecture, and the average roundness of subcellular structures.

Original language	English (US)
Title of host publication	Conference on Lasers and Electro-Optics, CLEO 2003
Publisher	Optica Publishing Group (formerly OSA)
ISBN (Electronic)	1557527334
State	Published - 2003
Event	Conference on Lasers and Electro-Optics, CLEO 2003 - Baltimore, United States Duration: Jun 1 2003 → Jun 6 2003

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Electronic)	2162-2701

Conference

Conference	Conference on Lasers and Electro-Optics, CLEO 2003
Country/Territory	United States
City	Baltimore
Period	6/1/03 → 6/6/03

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@inproceedings{a3fc82f22aed4530ab92d0e008735373,

title = "Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection",

abstract = "A novel instrument has been developed for the angular, spectral, azimuthal and polarization measurements of the light backscattering by living biological tissues. These measurements provide the most comprehensive quantitative information about the light scattering and allow obtaining unique quantitative information about the microarchitecture of living cells and tissues. We have shown the potential of this technique to characterize and diagnose very early premalignant changes in the epithelia, for which no histological or molecular markers has yet been established. Using this technique in our studies with a rodent model of colon carcinogenesis we obtained several parameters diagnostically significant for the detection of precancerous changes, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue microarchitecture, and the average roundness of subcellular structures.",

author = "Yang Liu and Kim, {Young L.} and Wali, {Ramesh K.} and Roy, {Hemant K.} and Goldberg, {Micheal J.} and Kromine, {Alexei K.} and Kun Chen and Vadim Backman",

note = "Publisher Copyright: {\textcopyright} 2003 OSA/CLEO 2003, {\textcopyright} 2000 Optical Society of America.; Conference on Lasers and Electro-Optics, CLEO 2003 ; Conference date: 01-06-2003 Through 06-06-2003",

year = "2003",

language = "English (US)",

series = "Optics InfoBase Conference Papers",

publisher = "Optica Publishing Group (formerly OSA)",

booktitle = "Conference on Lasers and Electro-Optics, CLEO 2003",

}

Liu, Y, Kim, YL, Wali, RK, Roy, HK, Goldberg, MJ, Kromine, AK, Chen, K & Backman, V 2003, Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection. in Conference on Lasers and Electro-Optics, CLEO 2003., CMG4, Optics InfoBase Conference Papers, Optica Publishing Group (formerly OSA), Conference on Lasers and Electro-Optics, CLEO 2003, Baltimore, United States, 6/1/03.

Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection. / Liu, Yang; Kim, Young L.; Wali, Ramesh K. et al.
Conference on Lasers and Electro-Optics, CLEO 2003. Optica Publishing Group (formerly OSA), 2003. CMG4 (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection

AU - Liu, Yang

AU - Kim, Young L.

AU - Wali, Ramesh K.

AU - Roy, Hemant K.

AU - Goldberg, Micheal J.

AU - Kromine, Alexei K.

AU - Chen, Kun

AU - Backman, Vadim

PY - 2003

Y1 - 2003

N2 - A novel instrument has been developed for the angular, spectral, azimuthal and polarization measurements of the light backscattering by living biological tissues. These measurements provide the most comprehensive quantitative information about the light scattering and allow obtaining unique quantitative information about the microarchitecture of living cells and tissues. We have shown the potential of this technique to characterize and diagnose very early premalignant changes in the epithelia, for which no histological or molecular markers has yet been established. Using this technique in our studies with a rodent model of colon carcinogenesis we obtained several parameters diagnostically significant for the detection of precancerous changes, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue microarchitecture, and the average roundness of subcellular structures.

AB - A novel instrument has been developed for the angular, spectral, azimuthal and polarization measurements of the light backscattering by living biological tissues. These measurements provide the most comprehensive quantitative information about the light scattering and allow obtaining unique quantitative information about the microarchitecture of living cells and tissues. We have shown the potential of this technique to characterize and diagnose very early premalignant changes in the epithelia, for which no histological or molecular markers has yet been established. Using this technique in our studies with a rodent model of colon carcinogenesis we obtained several parameters diagnostically significant for the detection of precancerous changes, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue microarchitecture, and the average roundness of subcellular structures.

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UR - http://www.scopus.com/inward/citedby.url?scp=85136284262&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85136284262

T3 - Optics InfoBase Conference Papers

BT - Conference on Lasers and Electro-Optics, CLEO 2003

PB - Optica Publishing Group (formerly OSA)

T2 - Conference on Lasers and Electro-Optics, CLEO 2003

Y2 - 1 June 2003 through 6 June 2003

ER -

Simultaneous Measurement of Angular and Spectral Properties of Light Scattering for Early Cancer Detection

Abstract

Publication series

Conference

ASJC Scopus subject areas

UN SDGs

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