Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography

Shuliang Jiao*, Zhixing Xie, Hao F. Zhang, Carmen A. Puliafito

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

We have developed a multimodal imaging technique by integrating photoacoustic microscopy and spectral- domain optical coherence tomography to provide simultaneous volumetric microscopic imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by imaging both the microanatomy and microvasculature in mouse ears in vivo.

Original languageEnglish (US)
Pages (from-to)2961-2963
Number of pages3
JournalOptics Letters
Volume34
Issue number19
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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