Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in their Mid-Fifties: What do we Really know about Environmental Factors?

Ari Pelcovits, Rachel Marriotti, Jonathan Heath, George Perry, Rudy J. Castellani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults. Case presentation: A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy. Conclusion: Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalOpen Neurology Journal
Volume9
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Alzheimer’s
  • Amyloid Beta
  • Dementia
  • Environmental Toxins
  • Neurofibrillary Tangles
  • Neuropathology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in their Mid-Fifties: What do we Really know about Environmental Factors?'. Together they form a unique fingerprint.

Cite this