Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in their Mid-Fifties: What do we Really know about Environmental Factors?

Ari Pelcovits; Rachel Marriotti; Jonathan Heath; George Perry; Rudy J. Castellani

doi:10.2174/1874205x01509010001

Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in their Mid-Fifties: What do we Really know about Environmental Factors?

Ari Pelcovits, Rachel Marriotti, Jonathan Heath, George Perry, Rudy J. Castellani^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Introduction: Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults. Case presentation: A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy. Conclusion: Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Open Neurology Journal
Volume	9
DOIs	https://doi.org/10.2174/1874205x01509010001
State	Published - 2015

Keywords

Alzheimer’s
Amyloid Beta
Dementia
Environmental Toxins
Neurofibrillary Tangles
Neuropathology

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health

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abstract = "Introduction: Environmental factors can play a role in the pathogenesis of Alzheimer{\textquoteright}s disease. We present a case of the simultaneous onset of Alzheimer{\textquoteright}s disease in two middle aged adults. Case presentation: A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer{\textquoteright}s disease within the same year. The patient{\textquoteright}s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy. Conclusion: Environmental factors may play a role in the pathogenesis of Alzheimer{\textquoteright}s disease. Further understanding of the disease cascade is required.",

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AU - Heath, Jonathan

AU - Perry, George

AU - Castellani, Rudy J.

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Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in their Mid-Fifties: What do we Really know about Environmental Factors?

Abstract

Keywords

ASJC Scopus subject areas

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