Single donor, HL-A matched platelet transfusions for thrombocytopenic patients undergoing surgery

Barry D. Kahan*, David Green, Alannah Ruder, David F. Ranney, Wilson H. Hartz, Kamal K. Mittal

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Thrombocytopenic patients, who displayed hemostatic disorders and had been previously sensitized by repeated blood transfusions and/or pregnancies, were supported for surgical procedures by platelet transfusions obtained from a single ABO and HL-A matched donor by the use of continuous collection centrifugation. Because of the low incidence of HL-A identical donors, compatibility was assessed by known serologic cross-reactivity of the HL-A determinants. In three cases repeated platelet transfusions had excellent in vivo survival, and sensitization could not be detected by a battery of immunological assays. In one case there was immune sensitization and refractoriness to repeated platelet transfusion, as documented by accelerated in vivo destruction of donor and third-party platelets bearing the disparate factor HL-A8. Although serologic tests for lymphocytotoxic and leukoagglutinating antibodies were negative, the patient displayed cellular immunity in leukocyte aggregation and cell-mediated plateletolysis tests. The single donor, continuous collection technique appears to have the technical advantage of rapid, efficient collection and the immunological benefit of a restricted spectrum of allosensitization.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalSurgery
Volume77
Issue number2
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Surgery

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    Kahan, B. D., Green, D., Ruder, A., Ranney, D. F., Hartz, W. H., & Mittal, K. K. (1975). Single donor, HL-A matched platelet transfusions for thrombocytopenic patients undergoing surgery. Surgery, 77(2), 241-248.