TY - JOUR
T1 - Single-dose cefuroxime axetil in the treatment of uncomplicated gonorrhea
T2 - A controlled trial
AU - Reichman, Richard C.
AU - Nolte, Frederick S.
AU - Wolinsky, Steven M.
AU - Greisberger, Carol A.
AU - Trupei, Mary Anne
AU - Nitzkin, Joel
PY - 1985
Y1 - 1985
N2 - One hundred eighty-four patients were enrolled in a randomized study that evaluated the efficacy and toxicity of a single dose of orally administered cefuroxine axetil in the treatment of men and women with uncomplicated gonorrhea. Sixty-two patients received cefuroxine axetil alone, 62 received cefuroxine axetil and probenecid, and 60 received amoxicillin plus probenecid. Cure rates in the three groups were 98%, 98%, 96%, respectively. Only 2% of patients who received cefuroxime axetil alone complained of nausea, as compared with 11% of those who received a regimen that contained probenecid (P < .05). The results show that cefuroxime axetil is effective and nontoxic in the treatment of uncomplicated gonococcal infections in adults.
AB - One hundred eighty-four patients were enrolled in a randomized study that evaluated the efficacy and toxicity of a single dose of orally administered cefuroxine axetil in the treatment of men and women with uncomplicated gonorrhea. Sixty-two patients received cefuroxine axetil alone, 62 received cefuroxine axetil and probenecid, and 60 received amoxicillin plus probenecid. Cure rates in the three groups were 98%, 98%, 96%, respectively. Only 2% of patients who received cefuroxime axetil alone complained of nausea, as compared with 11% of those who received a regimen that contained probenecid (P < .05). The results show that cefuroxime axetil is effective and nontoxic in the treatment of uncomplicated gonococcal infections in adults.
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U2 - 10.1097/00007435-198510000-00003
DO - 10.1097/00007435-198510000-00003
M3 - Article
C2 - 3936198
AN - SCOPUS:0022381015
SN - 0148-5717
VL - 12
SP - 184
EP - 187
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
IS - 4
ER -
