Single-dose cefuroxime axetil in the treatment of uncomplicated gonorrhea: A controlled trial

Richard C. Reichman*, Frederick S. Nolte, Steven M. Wolinsky, Carol A. Greisberger, Mary Anne Trupei, Joel Nitzkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

One hundred eighty-four patients were enrolled in a randomized study that evaluated the efficacy and toxicity of a single dose of orally administered cefuroxine axetil in the treatment of men and women with uncomplicated gonorrhea. Sixty-two patients received cefuroxine axetil alone, 62 received cefuroxine axetil and probenecid, and 60 received amoxicillin plus probenecid. Cure rates in the three groups were 98%, 98%, 96%, respectively. Only 2% of patients who received cefuroxime axetil alone com­plained of nausea, as compared with 11% of those who received a regimen that contained probenecid (P < .05). The results show that cefuroxime axetil is effective and nontoxic in the treatment of uncomplicated gonococcal infections in adults.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalSexually Transmitted Diseases
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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