Single injections of triazolam, a short-acting benzodiazepine, lengthen the period of the circadian activity rhythm in golden hamsters

J. E. Joy*, S. Losee-Olson, F. W. Turek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Single injections of the benzodiazepine, triazolam, induce phase shifts and cause a lengthening of the circadian activity rhythm in the golden hamster. The effect of triazolam on period depends on the phase of injection, but is not dependent on the direction of the phase shifts. Triazolam injections caused increases in period that were associated with phase advances as well as phase delays in the activity rhythm. This relationship between triazolam-induced phase shifts and changes in period is different from the relationship between light-induced phase shifts and period changes.

Original languageEnglish (US)
Pages (from-to)152-154
Number of pages3
JournalExperientia
Volume45
Issue number2
DOIs
StatePublished - Feb 1 1989

Keywords

  • Circadian rhythms
  • benzodiazepines
  • golden hamsters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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