Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases

Cheng Hung Tai; Cheng Chia Wu; Mark E. Hwang; Anurag Saraf; Christopher Grubb; Ashish Jani; Matthew E. Lapa; Jacquelyn I.S. Andrews; Steven R. Isaacson; Adam Mendel Sonabend Worthalter; Sameer A. Sheth; Guy M. McKhann; Michael B. Sisti; Jeffrey N. Bruce; Simon K. Cheng; Eileen P. Connolly; Tony Jc Wang

doi:10.2217/cns-2017-0023

Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases

Cheng Hung Tai, Cheng Chia Wu, Mark E. Hwang, Anurag Saraf, Christopher Grubb, Ashish Jani, Matthew E. Lapa, Jacquelyn I.S. Andrews, Steven R. Isaacson, Adam Mendel Sonabend Worthalter, Sameer A. Sheth, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Simon K. Cheng, Eileen P. Connolly, Tony Jc Wang

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & methods: We retrospectively gathered data from 127 breast cancer patients who underwent radiation therapy for brain metastasis. Patients were stratified by both breast GPA and modified breast GPA scores, and survival was determined using the Kaplan-Meier curves and Cox proportional hazards model. Results & Conclusion: The Kaplan-Meier curve for patients under the breast GPA classification were not significant, but were significant under the modified breast GPA classification. The inclusion of number of brain metastases into the modified breast GPA index improved prognosis, thus validating the use of the modified breast GPA in prognosticating patient outcome.

Original language	English (US)
Pages (from-to)	25-34
Number of pages	10
Journal	CNS oncology
Volume	7
Issue number	1
DOIs	https://doi.org/10.2217/cns-2017-0023
State	Published - Jan 2018

Keywords

brain tumor
metastasis
radiation therapy

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/cns-2017-0023

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Tai, C. H., Wu, C. C., Hwang, M. E., Saraf, A., Grubb, C., Jani, A., Lapa, M. E., Andrews, J. I. S., Isaacson, S. R., Sonabend Worthalter, A. M., Sheth, S. A., McKhann, G. M., Sisti, M. B., Bruce, J. N., Cheng, S. K., Connolly, E. P., & Wang, T. J. (2018). Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases. CNS oncology, 7(1), 25-34. https://doi.org/10.2217/cns-2017-0023

@article{13d91e18993a414c812909e6e3c814b3,

title = "Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases",

abstract = "Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & methods: We retrospectively gathered data from 127 breast cancer patients who underwent radiation therapy for brain metastasis. Patients were stratified by both breast GPA and modified breast GPA scores, and survival was determined using the Kaplan-Meier curves and Cox proportional hazards model. Results & Conclusion: The Kaplan-Meier curve for patients under the breast GPA classification were not significant, but were significant under the modified breast GPA classification. The inclusion of number of brain metastases into the modified breast GPA index improved prognosis, thus validating the use of the modified breast GPA in prognosticating patient outcome.",

keywords = "brain tumor, metastasis, radiation therapy",

author = "Tai, {Cheng Hung} and Wu, {Cheng Chia} and Hwang, {Mark E.} and Anurag Saraf and Christopher Grubb and Ashish Jani and Lapa, {Matthew E.} and Andrews, {Jacquelyn I.S.} and Isaacson, {Steven R.} and {Sonabend Worthalter}, {Adam Mendel} and Sheth, {Sameer A.} and McKhann, {Guy M.} and Sisti, {Michael B.} and Bruce, {Jeffrey N.} and Cheng, {Simon K.} and Connolly, {Eileen P.} and Wang, {Tony Jc}",

note = "Publisher Copyright: {\textcopyright} 2018 Tony JC Wang.",

year = "2018",

month = jan,

doi = "10.2217/cns-2017-0023",

language = "English (US)",

volume = "7",

pages = "25--34",

journal = "CNS oncology",

issn = "2045-0907",

publisher = "Future Medicine Ltd.",

number = "1",

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Tai, CH, Wu, CC, Hwang, ME, Saraf, A, Grubb, C, Jani, A, Lapa, ME, Andrews, JIS, Isaacson, SR, Sonabend Worthalter, AM, Sheth, SA, McKhann, GM, Sisti, MB, Bruce, JN, Cheng, SK, Connolly, EP & Wang, TJ 2018, 'Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases', CNS oncology, vol. 7, no. 1, pp. 25-34. https://doi.org/10.2217/cns-2017-0023

TY - JOUR

T1 - Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases

AU - Tai, Cheng Hung

AU - Wu, Cheng Chia

AU - Hwang, Mark E.

AU - Saraf, Anurag

AU - Grubb, Christopher

AU - Jani, Ashish

AU - Lapa, Matthew E.

AU - Andrews, Jacquelyn I.S.

AU - Isaacson, Steven R.

AU - Sonabend Worthalter, Adam Mendel

AU - Sheth, Sameer A.

AU - McKhann, Guy M.

AU - Sisti, Michael B.

AU - Bruce, Jeffrey N.

AU - Cheng, Simon K.

AU - Connolly, Eileen P.

AU - Wang, Tony Jc

PY - 2018/1

Y1 - 2018/1

N2 - Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & methods: We retrospectively gathered data from 127 breast cancer patients who underwent radiation therapy for brain metastasis. Patients were stratified by both breast GPA and modified breast GPA scores, and survival was determined using the Kaplan-Meier curves and Cox proportional hazards model. Results & Conclusion: The Kaplan-Meier curve for patients under the breast GPA classification were not significant, but were significant under the modified breast GPA classification. The inclusion of number of brain metastases into the modified breast GPA index improved prognosis, thus validating the use of the modified breast GPA in prognosticating patient outcome.

AB - Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & methods: We retrospectively gathered data from 127 breast cancer patients who underwent radiation therapy for brain metastasis. Patients were stratified by both breast GPA and modified breast GPA scores, and survival was determined using the Kaplan-Meier curves and Cox proportional hazards model. Results & Conclusion: The Kaplan-Meier curve for patients under the breast GPA classification were not significant, but were significant under the modified breast GPA classification. The inclusion of number of brain metastases into the modified breast GPA index improved prognosis, thus validating the use of the modified breast GPA in prognosticating patient outcome.

KW - brain tumor

KW - metastasis

KW - radiation therapy

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JO - CNS oncology

JF - CNS oncology

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Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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