Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

Asha Sarma, Paul B. Shyn*, Mark A. Vivian, Ju Mei Ng, Kemal Tuncali, Jorchen H. Lorch, Sarah N. Zaheer, Michael S. Gordon, Stuart G. Silverman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.

Original languageEnglish (US)
Pages (from-to)1335-1338
Number of pages4
JournalCardiovascular and Interventional Radiology
Volume38
Issue number5
DOIs
StatePublished - Oct 14 2015
Externally publishedYes

Keywords

  • Adrenal hyperplasia
  • Cushing’s syndrome
  • Ectopic ACTH syndrome
  • Image-guided intervention
  • Microwave ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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