Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

Asha Sarma; Paul B. Shyn; Mark A. Vivian; Ju Mei Ng; Kemal Tuncali; Jorchen H. Lorch; Sarah N. Zaheer; Michael S. Gordon; Stuart G. Silverman

doi:10.1007/s00270-015-1056-9

Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

Asha Sarma, Paul B. Shyn^*, Mark A. Vivian, Ju Mei Ng, Kemal Tuncali, Jorchen H. Lorch, Sarah N. Zaheer, Michael S. Gordon, Stuart G. Silverman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.

Original language	English (US)
Pages (from-to)	1335-1338
Number of pages	4
Journal	Cardiovascular and Interventional Radiology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1007/s00270-015-1056-9
State	Published - Oct 14 2015
Externally published	Yes

Keywords

Adrenal hyperplasia
Cushing’s syndrome
Ectopic ACTH syndrome
Image-guided intervention
Microwave ablation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

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10.1007/s00270-015-1056-9

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@article{1647c73c067141a4a23202169ce59d9d,

title = "Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome",

abstract = "Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing{\textquoteright}s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.",

keywords = "Adrenal hyperplasia, Cushing{\textquoteright}s syndrome, Ectopic ACTH syndrome, Image-guided intervention, Microwave ablation",

author = "Asha Sarma and Shyn, {Paul B.} and Vivian, {Mark A.} and Ng, {Ju Mei} and Kemal Tuncali and Lorch, {Jorchen H.} and Zaheer, {Sarah N.} and Gordon, {Michael S.} and Silverman, {Stuart G.}",

note = "Funding Information: Dr. Tuncali receives grant support from Canon, Inc. for unrelated projects. Dr. Lorch receives grant support from Novartis for unrelated projects. Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).",

year = "2015",

month = oct,

day = "14",

doi = "10.1007/s00270-015-1056-9",

language = "English (US)",

volume = "38",

pages = "1335--1338",

journal = "Cardiovascular and Interventional Radiology",

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}

TY - JOUR

T1 - Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

AU - Sarma, Asha

AU - Shyn, Paul B.

AU - Vivian, Mark A.

AU - Ng, Ju Mei

AU - Tuncali, Kemal

AU - Lorch, Jorchen H.

AU - Zaheer, Sarah N.

AU - Gordon, Michael S.

AU - Silverman, Stuart G.

N1 - Funding Information: Dr. Tuncali receives grant support from Canon, Inc. for unrelated projects. Dr. Lorch receives grant support from Novartis for unrelated projects. Publisher Copyright: © 2015, Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.

AB - Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.

KW - Adrenal hyperplasia

KW - Cushing’s syndrome

KW - Ectopic ACTH syndrome

KW - Image-guided intervention

KW - Microwave ablation

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DO - 10.1007/s00270-015-1056-9

M3 - Article

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AN - SCOPUS:84941416393

SN - 0174-1551

VL - 38

SP - 1335

EP - 1338

JO - Cardiovascular and Interventional Radiology

JF - Cardiovascular and Interventional Radiology

IS - 5

ER -

Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

Abstract

Keywords

ASJC Scopus subject areas

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