Single silver nanoparticles as real-time optical sensors with zeptomole sensitivity

Adam D. McFarland, Richard P. Van Duyne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1396 Scopus citations


This work utilizes dark-field optical microscopy to demonstrate the localized surface plasmon resonance λmax response of individual Ag nanoparticles to the formation of a monolayer of small-molecule adsorbates. The adsorption of fewer than 60 000 1-hexadecanethiol molecules on single Ag nanoparticles results in a localized surface plasmon resonance shift of 40.7 nm. Additionally, the kinetics of the single nanoparticle response was shown to be comparable to that of other real-time sensor technologies.

Original languageEnglish (US)
Pages (from-to)1057-1062
Number of pages6
JournalNano letters
Issue number8
StatePublished - Aug 1 2003

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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