Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: Early right hippocampal NAA/Cr loss in mildly impaired subjects

Maria T. Caserta; Ann Ragin; Adriana P. Hermida; R. John Ahrens; Leon Wise

doi:10.1016/j.pscychresns.2008.04.002

Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: Early right hippocampal NAA/Cr loss in mildly impaired subjects

Maria T. Caserta^*, Ann Ragin, Adriana P. Hermida, R. John Ahrens, Leon Wise

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this study, we use magnetic resonance spectroscopy (MRS) at 3 Tesla to measure N-acetyl aspartate (NAA), myo-inositol (mI) and choline (Cho) to creatine (Cr) ratios in R (right) and L (left) hippocampi (H) in 8 mildly memory impaired (MMI), 6 probable Alzheimer's Disease (PRAD), and 17 control subjects. NAA/Cr was significantly reduced in the RH in the MMI group and bilaterally in the PRAD group vs. controls. No other metabolite differences were noted between the three groups. Five MMI subjects have converted to PRAD in follow-up. These findings suggest that RH NAA/Cr ratios measured at 3 Tesla may be a sensitive marker of future progression to dementia in a clinically defined population with isolated memory complaints.

Original language	English (US)
Pages (from-to)	154-159
Number of pages	6
Journal	Psychiatry Research - Neuroimaging
Volume	164
Issue number	2
DOIs	https://doi.org/10.1016/j.pscychresns.2008.04.002
State	Published - Nov 30 2008

Keywords

Brain imaging
Hippocampus
N-acetyl aspartate
Temporal lobes

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2008.04.002

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title = "Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: Early right hippocampal NAA/Cr loss in mildly impaired subjects",

abstract = "In this study, we use magnetic resonance spectroscopy (MRS) at 3 Tesla to measure N-acetyl aspartate (NAA), myo-inositol (mI) and choline (Cho) to creatine (Cr) ratios in R (right) and L (left) hippocampi (H) in 8 mildly memory impaired (MMI), 6 probable Alzheimer's Disease (PRAD), and 17 control subjects. NAA/Cr was significantly reduced in the RH in the MMI group and bilaterally in the PRAD group vs. controls. No other metabolite differences were noted between the three groups. Five MMI subjects have converted to PRAD in follow-up. These findings suggest that RH NAA/Cr ratios measured at 3 Tesla may be a sensitive marker of future progression to dementia in a clinically defined population with isolated memory complaints.",

keywords = "Brain imaging, Hippocampus, N-acetyl aspartate, Temporal lobes",

author = "Caserta, {Maria T.} and Ann Ragin and Hermida, {Adriana P.} and Ahrens, {R. John} and Leon Wise",

note = "Funding Information: This work was supported part by a K07 award (NIMH 10156) to MTC and the Department of Psychiatry at the University of Chicago. We are grateful to Robert Lyons, Yiping Du, PhD, and David Levin, MD, PhD, from the Brain Research Imaging Center and Amy Levin, RN, from the Center for the Comprehensive Care and Research on Memory Disorders at the University of Chicago, the Northwestern Alzheimer's Disease Center (NADC) (AG13854) and the NADC Clinical Core.",

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AU - Caserta, Maria T.

AU - Ragin, Ann

AU - Hermida, Adriana P.

AU - Ahrens, R. John

AU - Wise, Leon

N1 - Funding Information: This work was supported part by a K07 award (NIMH 10156) to MTC and the Department of Psychiatry at the University of Chicago. We are grateful to Robert Lyons, Yiping Du, PhD, and David Levin, MD, PhD, from the Brain Research Imaging Center and Amy Levin, RN, from the Center for the Comprehensive Care and Research on Memory Disorders at the University of Chicago, the Northwestern Alzheimer's Disease Center (NADC) (AG13854) and the NADC Clinical Core.

PY - 2008/11/30

Y1 - 2008/11/30

N2 - In this study, we use magnetic resonance spectroscopy (MRS) at 3 Tesla to measure N-acetyl aspartate (NAA), myo-inositol (mI) and choline (Cho) to creatine (Cr) ratios in R (right) and L (left) hippocampi (H) in 8 mildly memory impaired (MMI), 6 probable Alzheimer's Disease (PRAD), and 17 control subjects. NAA/Cr was significantly reduced in the RH in the MMI group and bilaterally in the PRAD group vs. controls. No other metabolite differences were noted between the three groups. Five MMI subjects have converted to PRAD in follow-up. These findings suggest that RH NAA/Cr ratios measured at 3 Tesla may be a sensitive marker of future progression to dementia in a clinically defined population with isolated memory complaints.

AB - In this study, we use magnetic resonance spectroscopy (MRS) at 3 Tesla to measure N-acetyl aspartate (NAA), myo-inositol (mI) and choline (Cho) to creatine (Cr) ratios in R (right) and L (left) hippocampi (H) in 8 mildly memory impaired (MMI), 6 probable Alzheimer's Disease (PRAD), and 17 control subjects. NAA/Cr was significantly reduced in the RH in the MMI group and bilaterally in the PRAD group vs. controls. No other metabolite differences were noted between the three groups. Five MMI subjects have converted to PRAD in follow-up. These findings suggest that RH NAA/Cr ratios measured at 3 Tesla may be a sensitive marker of future progression to dementia in a clinically defined population with isolated memory complaints.

KW - Brain imaging

KW - Hippocampus

KW - N-acetyl aspartate

KW - Temporal lobes

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Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: Early right hippocampal NAA/Cr loss in mildly impaired subjects

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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