Singlet Oxygen Generation via Two-Photon Excited FRET

William R. Dichtel, Jason M. Serin, Carine Edder, Jean M J Fréchet, Michael Matuszewski, Loon Seng Tan, Tymish Y. Ohulchanskyy, Paras N. Prasad

Research output: Contribution to journalArticlepeer-review

200 Scopus citations

Abstract

A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

Original languageEnglish (US)
Pages (from-to)5380-5381
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number17
DOIs
StatePublished - May 5 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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