Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control

Victoria M. Wu, Joost Schulte, Alexander Hirschi, Ulrich Tepass, Greg J. Beitel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

Epithelial tubes of the correct size and shape are vital for the function of the lungs, kidneys, and vascular system, yet little is known about epithelial tube size regulation. Mutations in the Drosophila gene sinuous have previously been shown to cause tracheal tubes to be elongated and have diameter increases. Our genetic analysis using a sinuous null mutation suggests that sinuous functions in the same pathway as the septate junction genes neurexin and scribble, but that nervana 2, convoluted, varicose, and cystic have functions not shared by sinuous. Our molecular analyses reveal that sinuous encodes a claudin that localizes to septate junctions and is required for septate junction organization and paracellular barrier function. These results provide important evidence that the paracellular barriers formed by arthropod septate junctions and vertebrate tight junctions have a common molecular basis despite their otherwise different molecular compositions, morphologies, and subcellular localizations.

Original languageEnglish (US)
Pages (from-to)313-323
Number of pages11
JournalJournal of Cell Biology
Volume164
Issue number2
DOIs
StatePublished - Jan 19 2004

Keywords

  • Drosophila
  • Epithelial cell
  • Morphogenesis
  • Tight junction
  • Trachea

ASJC Scopus subject areas

  • Cell Biology

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