Sinus Infections, Inflammation, and Asthma

Anna G. Staudacher, Whitney W. Stevens*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

There is an important link between the upper and lower respiratory tracts whereby inflammation in one environment can influence the other. In acute rhinosinusitis, pathogen exposures are the primary driver for inflammation in the nose, which can exacerbate asthma. In chronic rhinosinusitis, a disease clinically associated with asthma, the inflammation observed is likely from a combination of an impaired epithelial barrier, dysregulated immune response, and potentially infection (or colonization) by specific pathogens. This review explores the associations between rhinosinusitis and asthma, with particular emphasis placed on the role of infections and inflammation.

Original languageEnglish (US)
Pages (from-to)403-415
Number of pages13
JournalImmunology and Allergy Clinics of North America
Volume39
Issue number3
DOIs
StatePublished - Aug 2019

Keywords

  • Acute rhinosinusitis
  • Asthma
  • Chronic rhinosinusitis
  • Infection
  • Inflammation
  • Microbiome
  • Nasal polyp

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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