Sinusoidal obstruction syndrome during maintenance therapy for acute lymphoblastic leukemia with 6-mercaptopurine and methotrexate: A pediatric case report

Kevin O. McNerney*, Juan C. Vasquez, Michael W. Kent, Joseph M. McNamara

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We report a case of a child with pre-B cell acute lymphoblastic leukemia undergoing maintenance chemotherapy with 6-mercaptopurine and methotrexate (MTX) who developed sinusoidal obstruction syndrome after being treated with ciprofloxacin for BK viremia. This case represents a rare complication of maintenance therapy with MTX and 6-mercaptopurine, and suggests a drug interaction between ciprofloxacin and MTX.

Original languageEnglish (US)
Pages (from-to)e454-e455
JournalJournal of pediatric hematology/oncology
Volume39
Issue number8
DOIs
StatePublished - 2017

Keywords

  • acute lymphoblastic leukemia
  • drug interaction
  • maintenance chemotherapy
  • sinusoidal obstruction syndrome
  • veno-occlusive disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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